4q1s

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==Yeast 20S proteasome in Complex with Kendomycin==
==Yeast 20S proteasome in Complex with Kendomycin==
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<StructureSection load='4q1s' size='340' side='right' caption='[[4q1s]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4q1s' size='340' side='right'caption='[[4q1s]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4q1s]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q1S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4q1s]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q1S FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2YD:(5R,6R,7S,8R,9R,12S,13E,16S,18S,19R,20AR)-4,7,19-TRIHYDROXY-2,6,8,12,14,16,18-HEPTAMETHYL-6,7,8,9,10,11,12,15,16,17,18,19,20,20A-TETRADECAHYDRO-1,19 5,9-DIEPOXYBENZO[18]ANNULEN-3(5H)-ONE'>2YD</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ryp|1ryp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2YD:(5R,6R,7S,8R,9R,12S,13E,16S,18S,19R,20AR)-4,7,19-TRIHYDROXY-2,6,8,12,14,16,18-HEPTAMETHYL-6,7,8,9,10,11,12,15,16,17,18,19,20,20A-TETRADECAHYDRO-1,19 5,9-DIEPOXYBENZO[18]ANNULEN-3(5H)-ONE'>2YD</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1s OCA], [https://pdbe.org/4q1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q1s RCSB], [https://www.ebi.ac.uk/pdbsum/4q1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q1s ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q1s RCSB], [http://www.ebi.ac.uk/pdbsum/4q1s PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSB6_YEAST PSB6_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4q1s" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Proteasome 3D structures|Proteasome 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Beck, P.]]
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[[Category: Beck P]]
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[[Category: Elnakady, Y.]]
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[[Category: Elnakady Y]]
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[[Category: Groll, M.]]
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[[Category: Groll M]]
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[[Category: Heinemeyer, W.]]
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[[Category: Heinemeyer W]]
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[[Category: Mueller, R.]]
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[[Category: Mueller R]]
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[[Category: Spaeth, A.]]
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[[Category: Spaeth A]]
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[[Category: Covalent binding]]
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[[Category: Exosite]]
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[[Category: Hydrolase-toxin complex]]
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[[Category: Natural product]]
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[[Category: Proteasome]]
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[[Category: Quinone methide]]
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Current revision

Yeast 20S proteasome in Complex with Kendomycin

PDB ID 4q1s

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