This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Fibrin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:49, 2 March 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
 +
<StructureSection load='1n73' size='350' side='right' scene='41/417472/Cv/3' caption='Fibrin α1 subunit (red, yellow), β subunit (cyan, blue), γ subunit (orange, magenta) from Petromyzon marinus (PDB entry [[1n73]])'>
-
{{STRUCTURE_1n73| PDB=1n73 | SIZE=400| SCENE=Fibrin/Cv/2 |right|CAPTION=Fibrin α1 subunit (red, yellow), β subunit (Green, blue), γ subunit (orange, magenta) from ''Petromyzon marinus'', [[1n73]] }}
+
== Function ==
-
[[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). The images at the left and at the right correspond to one representative Fibrin, ''i.e.'' the crystal structure of Fibrin from ''Petromyzon marinus'' ([[1n73]]).
+
[[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa)<ref>PMID:12501189</ref>.
-
{{TOC limit|limit=2}}
+
== Disease ==
 +
Overexpression of FIa can cause thrombosis.
 +
 +
== Structural highlights ==
 +
 +
<scene name='41/417472/Cv/6'>Ca coordination site in β subunit</scene>.
 +
 +
<scene name='41/417472/Cv/7'>Ca coordination site in γ subunit</scene> (PDB entry [[1n73]]).
 +
</StructureSection>
== 3D Structures of Fibrin ==
== 3D Structures of Fibrin ==
Line 14: Line 23:
[[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br />
[[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br />
[[1n8e]] - hFIa α, β, γ chains <br />
[[1n8e]] - hFIa α, β, γ chains <br />
-
[[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br />
+
[[2a45]] - hFIa α, β, γ chains + thrombin<br />
[[1fzc]] – hDDFIa+peptide<br />
[[1fzc]] – hDDFIa+peptide<br />
 +
[[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br />
 +
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Fibrin α1 subunit (red, yellow), β subunit (cyan, blue), γ subunit (orange, magenta) from Petromyzon marinus (PDB entry 1n73)

Drag the structure with the mouse to rotate

3D Structures of Fibrin

Updated on 02-March-2023

3h32 – hFIa peptide+ hFI α, β, γ chains – human
2q9i, 2z4e - hFIa B-knob+ hFI α, β, γ chains
2hlo, 1n86 - hFIa α, β, γ chains + peptide
1n8e - hFIa α, β, γ chains
2a45 - hFIa α, β, γ chains + thrombin
1fzc – hDDFIa+peptide
1n73 - FIa α, β, γ chains + peptide – Sea lamprey

References

  1. ↑ Yang Z, Pandi L, Doolittle RF. The crystal structure of fragment double-D from cross-linked lamprey fibrin reveals isopeptide linkages across an unexpected D-D interface. Biochemistry. 2002 Dec 31;41(52):15610-7. PMID:12501189

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

Retrieved from "http://52.214.119.220/wiki/index.php/Fibrin"
Personal tools