4myp

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'''Unreleased structure'''
 
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The entry 4myp is ON HOLD until Mar 15 2016
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==Structure of the central NEAT domain, N2, of the listerial Hbp2 protein complexed with heme==
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<StructureSection load='4myp' size='340' side='right'caption='[[4myp]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Malmirchegini, G.R., Sawaya, M.R., Clubb, R.T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4myp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MYP FirstGlance]. <br>
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Description: Structure of the central NEAT domain, N2, of the listerial Hbp2 protein complexed with heme
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4myp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4myp OCA], [https://pdbe.org/4myp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4myp RCSB], [https://www.ebi.ac.uk/pdbsum/4myp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4myp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HBP2_LISMO HBP2_LISMO] Acts as an extracellular and cell wall-bound hemophore; scavenges host heme and hemoglobin from the environment and also serves as a cell wall receptor for both (Probable). At low hemin (Hn) and hemoglobin (Hb) concentrations adsorbs Hn/Hb and presumably directs it to membrane transporters (Probable). Soluble Hbp2 can probably pass Hn/Hb to cell wall-anchored Hbp2, and both forms can accept Hn/Hb from Hbp1 (PubMed:25315777). May be involved in crossing the digestive barrier in infected animals (PubMed:15661014). Binds host hemin (Probable) (PubMed:21545655, PubMed:25315777). Binds host hemoglobin with affinity in the nanomolar range (PubMed:25315777).<ref>PMID:15661014</ref> <ref>PMID:21545655</ref> <ref>PMID:25315777</ref> <ref>PMID:15661014</ref> <ref>PMID:21545655</ref> <ref>PMID:25315777</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Listeria monocytogenes]]
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[[Category: Clubb RT]]
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[[Category: Malmirchegini GR]]
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[[Category: Sawaya MR]]

Current revision

Structure of the central NEAT domain, N2, of the listerial Hbp2 protein complexed with heme

PDB ID 4myp

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