3kw6
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==Crystal Structure of a domain of 26S proteasome regulatory subunit 8 from homo sapiens. Northeast Structural Genomics Consortium target id HR3102A== | ==Crystal Structure of a domain of 26S proteasome regulatory subunit 8 from homo sapiens. Northeast Structural Genomics Consortium target id HR3102A== | ||
| - | <StructureSection load='3kw6' size='340' side='right' caption='[[3kw6]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='3kw6' size='340' side='right'caption='[[3kw6]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3kw6]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3kw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KW6 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kw6 OCA], [https://pdbe.org/3kw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kw6 RCSB], [https://www.ebi.ac.uk/pdbsum/3kw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kw6 ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRS8_HUMAN PRS8_HUMAN] The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/3kw6_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/3kw6_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kw6 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | + | *[[Proteasome 3D structures|Proteasome 3D structures]] | |
| - | *[[Proteasome|Proteasome]] | + | |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Acton | + | [[Category: Large Structures]] |
| - | [[Category: Baran | + | [[Category: Acton TB]] |
| - | [[Category: Cunningham | + | [[Category: Baran MC]] |
| - | [[Category: Hunt | + | [[Category: Cunningham K]] |
| - | [[Category: Janjua | + | [[Category: Hunt JF]] |
| - | [[Category: Liu | + | [[Category: Janjua H]] |
| - | [[Category: Montelione | + | [[Category: Liu J]] |
| - | + | [[Category: Montelione GT]] | |
| - | [[Category: Owens | + | [[Category: Owens L]] |
| - | [[Category: Seetharaman | + | [[Category: Seetharaman J]] |
| - | [[Category: Su | + | [[Category: Su M]] |
| - | [[Category: Tong | + | [[Category: Tong L]] |
| - | [[Category: Wang | + | [[Category: Wang D]] |
| - | [[Category: Xiao | + | [[Category: Xiao R]] |
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Current revision
Crystal Structure of a domain of 26S proteasome regulatory subunit 8 from homo sapiens. Northeast Structural Genomics Consortium target id HR3102A
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Categories: Homo sapiens | Large Structures | Acton TB | Baran MC | Cunningham K | Hunt JF | Janjua H | Liu J | Montelione GT | Owens L | Seetharaman J | Su M | Tong L | Wang D | Xiao R
