4yia
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4yia is ON HOLD Authors: Zheng, Y. Description: Strutural mechanism of hormone in thyroxine binding globulin Category: Unreleased Structures [[...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural mechanism of hormone release in thyroxine binding globulin== | |
| + | <StructureSection load='4yia' size='340' side='right'caption='[[4yia]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4yia]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YIA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMN:INDOMETHACIN'>IMN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yia OCA], [https://pdbe.org/4yia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yia RCSB], [https://www.ebi.ac.uk/pdbsum/4yia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yia ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:[https://omim.org/entry/314200 314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN] Major thyroid hormone transport protein in serum. | ||
| - | + | ==See Also== | |
| - | + | *[[Serpin 3D structures|Serpin 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Zheng | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Zheng Y]] | ||
Current revision
Structural mechanism of hormone release in thyroxine binding globulin
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