Nonstructural protein

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{{STRUCTURE_3o9s| PDB=3o9s | SIZE=400| SCENE= |right|CAPTION=Nonstructural protein dimer [[3o9s]] }}
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<StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'>
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__TOC__
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[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle. Pestivirus encode a NS at the N-terminal of their poluproteins (Npro). For homology model and multiple sequence alignment see<br />
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[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see<br />
*[[User:Michael Strong/H1N1/NS]]<br />
*[[User:Michael Strong/H1N1/NS]]<br />
*[[User:Michael Strong/H1N1/NS1/MSA]]<br />
*[[User:Michael Strong/H1N1/NS1/MSA]]<br />
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*[[User:Michael Strong/H1N1/NS2/MSA]].
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*[[User:Michael Strong/H1N1/NS2/MSA]]<br />
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*[[Student Project 4 for UMass Chemistry 423 Spring 2015]].
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<br />
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For NS1 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP1]].<br />
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For NS2 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP2]].<br />
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For NS3 of SARS-CoV-2 see [[SARS-CoV-2 enzyme Papain-like]].<br />
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For NS4 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP4]].<br />
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For NS6 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP6]].<br />
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For NS7 or '''replicase polyprotein 1ab light chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP7]].<br />
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For NS8 or '''replicase polyprotein 1ab heavy chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP8]].<br />
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For NS9 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP9]].<br />
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For NS10 or '''replicase polyprotein 1ab''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP10]].<br />
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For NS12 of SARS-CoV-2 see also [[Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 vi]].<br />
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For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see [[SARS-CoV-2 enzyme RdRp]].<br />
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SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called '''replication-transcription complex'''.<br />
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For NS16+NS10 of SARS-CoV-2 see [[SARS-CoV-2 enzyme 2'-O-MT]].
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== 3D Structures of Nonstructural protein ==
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== Relevance ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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The drug Victrelis (generic name boceprevir) binds to NS3 of the hepatitis C virus and is used for treatment of the disease. See [[Bailey Dove/Victrelis]].
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Nonstructural protein
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== Structural highlights ==
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<scene name='46/461364/Cv/4'>Hepatitis virus NS active site shows hydrogen bond interactions and hydrophobic pocket interactions</scene><ref>PMID:12509436</ref>.
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**[[3o9q]], [[4opa]], [[4oph]] – IvNS1 (mutant) – Influenza virus<br />
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== 3D Structures of Nonstructural protein ==
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**[[3o9r]], [[3o9s]], [[3o9t]], [[3o9u]], [[3f5t]] – IvNS1<br />
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[[Nonstructural protein 3D structures]]
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**[[3m8a]], [[2z0a]], [[1xeq]], [[1ail]] – IvNS1 RNA-binding domain<br />
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**[[3p31]] – IvNS1 C terminal effector domain<br />
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**[[3p38]], [[3p39]] – IvNS1 C terminal effector domain (mutant)<br />
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**[[1ns1]] - IvNS1 RNA-binding domain - NMR<br />
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**[[3m5r]], [[2gx9]] - IvNS1 effector domain<br />
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**[[1pd3]] – IvNS2 M1-binding domain<br />
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**[[3l6p]], [[3lkw]] – DvNS2B/3 protease domain (mutant) – Dentue virus<br />
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**[[2o1j]] – RvNSP4 diarrhea-inducing domain – Rotavirus<br />
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**[[2gu0]] – RvNS2<br />
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**[[2ajj]], [[2ajm]], [[2ajn]], [[2ajo]] – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR<br />
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**[[1fw5]] – NSP1 membrane-binding domain – Semliki forest virus – NMR<br />
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**[[1qol]] – NSP20A (mutant) - Foot-and-mouth disease virus<br />
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**[[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus<br />
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**[[1r7c]], [[1r7d]], [[1r7e]], [[1r7f]], [[1r7g]] - HvNS5A membrane-anchor domain - NMR<br />
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**[[2gdt]], [[2hsx]] – SvNS1 (mutant) – Sars coronavirus – NMR<br />
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**[[2jzd]], [[2jze]], [[2jzf]], [[2rnk]] – SvNS3 residues 527-651 – NMR<br />
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**[[2kaf]] - SvNS3 residues 1473-1532 – NMR <br />
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**[[2kys]] – SvNS7 – NMR<br />
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**[[2l8k]] – NS7 residues 1454-1575 – NMR<br />
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**[[3mtv]] – NS1 residues 181-383 – PRRS virus <br />
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**[[3zfn]], [[3zfo]], [[3zfq]], [[3zfp]], [[3zfr]], [[3zft]], [[3zfu]] – Npro (mutant) – Pestivirus<br />
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**[[4r05]] – DvNS5 residues 2491-2752 – Dengue virus<br />
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**[[4x2z]] – NS3 residues 1174-1483 – Avian infectious bronchitis virus<br />
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*Nonstructural protein binary complex
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**[[2xbm]] – DvNS5 methyltransferase domain + RNA<br />
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</StructureSection>
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**[[2hye]] – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5<br />
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**[[2b5l]] - SvNSV + DNA damage-binding protein<br />
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**[[1nhv]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor<br />
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**[[1dxp]], [[1dy8]], [[1dy9]], [[1w3c]] – HvNS4A + HvHelicase NS3<br />
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**[[4k8b]] - HvNS4A + HvProtease NS3 + inhibitor<br />
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**[[4a1t]], [[4a1x]] - HvNS4A + peptide inhibitor<br />
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**[[3phe]] – HvNS5B + quinolone derivative<br />
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**[[3ub0]] – NSP6 + NSP7 – Feline infectious peritonitis virus<br />
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**[[1knz]] – RvNSP34 N terminal + mRNA<br />
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**[[1lj2]] – RvNSP34 C terminal + eukaryotic protein synthesis initiation factor peptide<br />
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**[[4r8r]] – DvNS5 residues 2491-2752 + adenosyl-Met<br />
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**[[4r8s]] – DvNS5 residues 2491-2752 + sinefungin<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry 1nhu)

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References

  1. ↑ Zhu Z, Shi Z, Yan W, Wei J, Shao D, Deng X, Wang S, Li B, Tong G, Ma Z. Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity. PLoS One. 2013;8(2):e55920. doi: 10.1371/journal.pone.0055920. Epub 2013 Feb 6. PMID:23405236 doi:http://dx.doi.org/10.1371/journal.pone.0055920
  2. ↑ Wang M, Ng KK, Cherney MM, Chan L, Yannopoulos CG, Bedard J, Morin N, Nguyen-Ba N, Alaoui-Ismaili MH, Bethell RC, James MN. Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem. 2003 Mar 14;278(11):9489-95. Epub 2002 Dec 30. PMID:12509436 doi:10.1074/jbc.M209397200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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