Virus protease

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:59, 18 February 2021) (edit) (undo)
 
(27 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_1odw| PDB=1odw | SIZE=400| SCENE=Virus_protease/Cv/1 |right|CAPTION=HIV-1 protease dimer complex with tert-butylcarbonate [[1odw]] }}
+
<StructureSection load='' size='350' side='right' caption='Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry [[1cqq]])' scene='55/554890/Cv/1'>
 +
__TOC__
 +
== Function ==
 +
 +
'''Virus protease''' or '''3C protease''' or '''virus proteinase''' are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref> F
 +
 
 +
== Disease ==
 +
 
 +
Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus. Coxsakievirus causes the human diseases myocarditis and pericarditis.
 +
 
 +
== Structural highlights ==
 +
 
 +
Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The <scene name='55/554890/Cv/6'>active site triad contains Cys147, His40 and Glu71</scene> (PDB entry [[1cqq]]).<ref>PMID:10500114</ref> <scene name='55/554890/Cv/5'>Whole binding site</scene>.
-
'''Virus proteases''' include HIV protease, XMRV protease, retropepsin.
 
-
HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa.
 
See also<br />
See also<br />
-
 
+
*[[Immunodeficiency virus protease]]<br />
*[[Human Immunodeficiency Virus]]<br />
*[[Human Immunodeficiency Virus]]<br />
*[[HIV-1 protease]]<br />
*[[HIV-1 protease]]<br />
Line 13: Line 23:
*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
-
*[[Molecular Playground/Dengue Virus Protease]]
+
*[[FMDV 3C]] for Foot-and-Mouth virus protease<br />
-
 
+
*[[SARS Coronavirus Main Proteinase]]<br />
-
== 3D Structures of Virus proteases ==
+
*[[SARS-CoV-2 Coronavirus Main Protease]]<br />
-
 
+
*[[Taylor SARS-CoV2 Protease]]<br />
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
== 3D Structures of Virus protease ==
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
[[Virus protease 3D structures]]
-
 
+
</StructureSection>
-
*'''HIV-1 protease'''
+
-
 
+
-
**[[3ixo]] - HIV1-PR subtype A<br />
+
-
**[[1odx]], [[2hb2]], [[2hb4]], [[2pc0]], [[3bva]], [[3mws]], [[3kt2]], [[3kt5]], [[4ej8]], [[4ejl]] - HIV1-PR (mutant) <br />
+
-
**[[1rpi]], [[1rq9]], [[1tw7]], [[3oq7]], [[3oqa]], [[3oqd]], [[3pj6]], [[3uf3]], [[3o99]], [[3o9a]], [[3o9b]], [[3o9c]], [[3o9d]], [[3o9e]], [[3o9f]], [[3o9g]], [[3o9h]], [[3o9i]], [[3u71]] - HIV1-PR (drug-resistant mutant) <br />
+
-
**[[1odw]], [[3kf1]], [[3hvp]], [[3phv]] - HIV1-PR<br />
+
-
**[[3fsm]], [[3hlo]] - HIV1-PR covalent dimer
+
-
 
+
-
*HIV-1 protease complexes
+
-
 
+
-
**[[1hsg]], [[1hsh]], [[1hsi]], [[3oxc]], [[3ekv]], [[3ekx]], [[3eky]], [[3el1]], [[1ohr]], [[3ndt]], [[3nls]], [[3qoz]], [[3ndu]], [[3ndw]], [[3ndx]], [[3qoz]], [[3r0w]], [[3r0y]], [[4dqb]], [[4jec]], [[4hla]] - HIV1-PR + antiviral drug<br />
+
-
**[[4eyr]], [[4j54]], [[4j55]], [[4j5j]] - HIV1-PR (mutant) + antiviral drug<br />
+
-
**[[1aid]], [[1qbr]], [[1qbs]], [[1qbt]], [[1qbu]], [[3mxe]], [[3m9f ]], [[3kf0]], [[3kf1]], [[3kfn]], [[3kfp]], [[3kfr]], [[3kfs]], [[2wkz]], [[2wl0]], [[3gga]], [[3ggv]], [[3ggx]], [[2uxz]], [[2uy0]], [[1zp8]], [[1xl2]], [[1xl5]], [[1zpa]], [[1yt9]], [[2a4f]], [[1upj]], [[2upj]], [[7upj]], [[1hxb]], [[1hih]], [[1hvr]], [[1hef]], [[1heg]], [[4phv]], [[1w5w]], [[1w5x]], [[1w5v]], [[1w5y]], [[1t7k]], [[1npa]], [[1npv]], [[1npw]], [[1eby]], [[1ec0]], [[1g2k]], [[1c6x]], [[1c6y]], [[1c6z]], [[1hwr]], [[2bpv]], [[2bpw]], [[2bpx]], [[ 2bpy]], [[ 2bpz]], [[ 1ody]], [[1hvh]], [[3tlh]], [[1hxw]], [[3bvb]], [[3ckt]], [[3mxd]], [[3hau]], [[3haw]], [[3hbo]], [[3hdk]], [[3i2l]], [[3ia9]], [[3r4b]], [[3bgb]], [[3bgc]], [[3bhe]], [[3gi4]], [[3gi5]], [[3gi6]], [[3nwq]], [[3nwx]], [[3nyg]], [[3psu]], [[3t11]], [[4fe6]], [[4a4q]], [[4i8w]], [[4i8z]] - HIV1-PR + inhibitor<br />
+
-
**[[2zye]] - HIV1-PR + inhibitor - neutron<br />
+
-
**[[3aid]], [[1ytg]], [[1yth]], [[2nxd]], [[2nxl]], [[2nxm]], [[2fns]], [[2fnt]], [[1zj7]], [[1zlf]], [[1zpk]], [[1zsf]], [[1zsr]], [[1cpi]], [[1m0b]], [[1iiq]], [[1fqx]], [[1a30]] - HIV1-PR + polypeptide derivative<br />
+
-
**[[3gi0]] - HIV1-PR covalent dimer + polypeptide<br />
+
-
**[[3hzc]], [[3iaw]], [[3ka2]], [[3nxn]] - HIV1-PR covalent dimer + inhibitor<br />
+
-
**[[1sp5]] - HIV1-PR + autoproteolytic peptide<br />
+
-
**[[4ep2]], [[4epj]], [[4eq0]], [[4eqj]] - HIV1-PR + substrate<br />
+
-
**[[4ejd]], [[4ejk]] - HIV1-PR + pepstatin<br />
+
-
**[[4f73]]- HIV1-PR + CA-P2<br />
+
-
**[[4f74]]- HIV1-PR + MA-CA<br />
+
-
**[[4f75]]- HIV1-PR + RH-IN<br />
+
-
**[[4f76]]- HIV1-PR + P1-P6<br />
+
-
 
+
-
*HIV-1 protease (mutant) complexes
+
-
 
+
-
**[[3nu3]], [[3nu4]], [[3nu5]], [[3nu6]], [[3nu9]], [[3nuj]], [[3nuo]], [[2qhc]], [[2qak]], [[2pym]], [[2pyn]], [[2q63]], [[2q64]], [[2fxd]], [[2fxe]], [[2fgu]], [[2fgv]], [[1sdt]], [[1sdu]], [[1sdv]], [[1d4y]], [[1d4s]], [[3cyw]], [[3cyx]], [[3d1x]], [[3d1y]], [[3d1z]], [[3d20]], [[3djk]], [[3dk1]], [[3n3i]], [[3oxv]], [[3oxw]], [[3oxx]], [[3oy4]], [[3k4v]], [[3lzs]], [[3lzu]], [[3lzv]], [[3so9]], [[3spk]], [[3ufn]], [[4dqh]], [[3s43]], [[3s53]], [[3s54]], [[3s56]], [[4dqc]], [[4dqe]], [[4dqf]], [[4dqg]] - HIV1-PR (mutant) + antiviral drug<br />
+
-
**[[2aid]], [[1hpo]], [[1tcx]], [[1gnm]], [[1gnn]], [[1gno]], [[1kzk]], [[3ok9]], [[3i8w]], [[3i7e]], [[3bxr]], [[3bxs]], [[2hc0]], [[2psu]], [[2psv]], [[2fle]], [[2f3k]], [[2ien]], [[2fdd]], [[2fde]], [[1t7i]], [[1t3r]], [[1mrw]], [[1mrx]], [[1msm]], [[1msn]], [[1bv9]], [[3h5b]], [[3kdb]], [[3kdc]], [[3kdd]], [[3a2o]], [[3bc4]], [[3fx5]], [[3i6o]], [[3st5]], [[3qaa]], [[3qbf]], [[3qih]], [[3qn8]], [[3qp0]], [[3qpj]], [[3qrm]], [[3qro]], [[3qrs]], [[4dfg]] - HIV1-PR (mutant) + inhibitor<br />
+
-
**[[2p3b]] - HIV1-PR subtype B (mutant) + inhibitor<br />
+
-
**[[2p3c]] - HIV1-PR subtype F (mutant) + inhibitor<br />
+
-
**[[1zbg]], [[1z8c]], [[2az9]], [[2azc]], [[2a1e]], [[1lzq]], [[1d4k]], [[1d4l]], [[1a8k]], [[1a94]], [[1axa]], [[3dox]], [[3d3t]], [[4fl8]] - HIV1-PR (mutant) + polypeptide derivative<br />
+
-
**[[1ztz]] - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane<br />
+
-
**[[3b7v]], [[3b80]], [[3mim]] - HIV1-PR (mutant) + autoproteolytic polypeptide + tetrahedral intermediate<br />
+
-
**[[3nxe]] - HIV1-PR covalent dimer (mutant) + inhibitor<br />
+
-
**[[4flg]], [[4fm6]] - HIV1-PR (mutant) + reaction intermediate
+
-
 
+
-
*HIV-1 protease (drug-resistant mutant) complexes
+
-
 
+
-
**[[3el4]], [[3el9]], [[3em3]], [[3em4]], [[3em6]], [[3ggt]], [[3ggu]], [[1t7j]], [[1rv7]], [[1n49]], [[1fb7]], [[3ekp]], [[3ekq]], [[3ekt]], [[3ekw]], [[3el0]], [[3el5]], [[3pwm]], [[3pwr]], [[3ucb]], [[3uhl]], [[3ttp]] - HIV1-PR (drug-resistant mutant) + antiviral drug<br />
+
-
**[[3ots]], [[3oty]], [[3ou1]], [[3ou3]], [[3ou4]], [[3oua]], [[3oub]], [[3ouc]], [[3oud]] - HIV1-PR (drug-resistant mutant) + peptide<br />
+
-
**[[1izh]], [[ 1izi]], [[1fb7]], [[3t3c]], [[4fae]], [[4faf]], [[3sa3]], [[3sa4]], [[3sa5]], [[3sa6]], [[3sa7]], [[3sa8]], [[3sa9]], [[3saa]], [[3sab]], [[3sac]], [[3vf5]], [[3vf7]], [[3vfa]], [[3vfb]] - HIV1-PR (drug-resistant mutant) + inhibitor<br />
+
-
**[[2p3a]] - HIV1-PR subtype B (drug-resistant mutant) + inhibitor<br />
+
-
**[[2p3d]] - HIV1-PR subtype F (drug-resistant mutant) + inhibitor<br />
+
-
 
+
-
*'''HIV-2 protease'''
+
-
 
+
-
**[[1jld]] - HIV2-PR<br />
+
-
**[[1hii]] - HIV2-PR + inhibitor<br />
+
-
**[[5upj]], [[ 6upj]], [[ 3upj]], [[ 4upj]] - HIV2-PR (mutant) + inhibitor<br />
+
-
**[[1ida]], [[ 1idb]], [[ 2mip]] - HIV2-PR + polypeptide derivative
+
-
 
+
-
*'''Feline Immunodeficiency virus protease'''
+
-
+
-
**[[2hah]], [[4fiv]] - FIV-PR residues 39-154 (mutant) + inhibitor<br />
+
-
**[[3ogp]], [[3ogq]] - FIV-PR residues 39-154 (mutant) + drug<br />
+
-
**[[5fiv]], [[ 6fiv]], [[ 1b11]] - FIV-PR + inhibitor<br />
+
-
**[[2fiv]], [[3fiv]] - SIV-PR (mutant) + substrate
+
-
+
-
*'''Simian Immunodeficiency virus protease'''
+
-
+
-
**[[2sam]] - SIV-PR + inhibitor<br />
+
-
**[[1az5]] - SIV-PR (mutant)<br />
+
-
 
+
-
*'''Xenotropic murine leukemia virus protease'''
+
-
 
+
-
**[[3nr6]] – XMRV-PR P14<br />
+
-
**[[3p1g]] – XMRV-PR RNase H domain (mutant)
+
-
 
+
-
*'''Rous sarcoma virus protease'''
+
-
 
+
-
**[[1bai]] – RSVP + polypeptide inhibitor _ Rous sarcoma virus
+
-
 
+
-
*'''Human Cytomegalovirus protease'''
+
-
 
+
-
**[[1cmv]], [[1lay]] – CMVP (mutant) – human herpes virus 5<br />
+
-
**[[1wpo]] – CMVP<br />
+
-
**[[2wpo]] - CMVP (mutant) + inhibitor
+
-
 
+
-
*'''Varicella-Zoster virus protease'''
+
-
 
+
-
**[[1vzv]] - VZVP (mutant) – human herpes virus
+
-
 
+
-
*'''Equine infectious anemia virus protease'''
+
-
 
+
-
**[[2fmb]] – EIAVP (mutant) + inhibitor
+
-
 
+
-
*'''Hepatitis A virus protease'''
+
-
 
+
-
**[[2h9h]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
+
-
 
+
-
*'''Hepatitis C virus protease'''
+
-
 
+
-
**[[2o8m]] – HCVP (mutant)<br />
+
-
 
+
-
*'''Orf 17'''
+
-
 
+
-
**[[3njq]] – hOrf 17 - human herpes virus 8
+
-
 
+
-
*'''Dengue virus protease'''
+
-
 
+
-
**[[3u1i]] – DvNs2b + peptide – Dengue virus<br />
+
-
**[[3u1j]] – DvNs2b + BPTI<br />
+
-
**[[2fom]] - DvNs2b + DvNs3<br />
+
-
**[[2whx]] – DvNs3 residues 1475-2092
+
-
 
+
-
*'''Herpes simplex virus protease'''
+
-
 
+
-
**[[1at3]] – HSV II – human herpesvirus 2
+
-
 
+
-
*'''Foot-and-Mouth Disease virus protease'''
+
-
 
+
-
**[[2bhg]] – FMDV – Foot-and-mouth disease virus
+
-
 
+
-
*'''Infectious Bronchitis virus protease'''
+
-
 
+
-
**[[2q6d]] – IBV – infectious bronchitis virus <br />
+
-
**[[2q6f]] – IBV + inhibitor
+
-
 
+
-
*'''Yellowtail ascites virus protease'''
+
-
 
+
-
**[[4izj]], [[4izk]] – YAV Vp4 (mutant) – yellowtail ascites virus
+
-
 
+
-
*'''Pseudorabies virus protease'''
+
-
 
+
-
**[[4cx8]] – YAV – pseudorabies virus<br />
+
-
}}
+
==References==
 +
<references />
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry 1cqq)

Drag the structure with the mouse to rotate

References

  1. ↑ Wanga QM, Chen SH. Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept Sci. 2007 Feb;8(1):19-27. PMID:17305557
  2. ↑ Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7. PMID:10500114

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Virus_protease"
Personal tools