4x6z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Yeast 20S proteasome in complex with PR-VI modulator== | |
| + | <StructureSection load='4x6z' size='340' side='right'caption='[[4x6z]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4x6z]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X6Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x6z OCA], [https://pdbe.org/4x6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x6z RCSB], [https://www.ebi.ac.uk/pdbsum/4x6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x6z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSB6_YEAST PSB6_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | ||
| - | + | ==See Also== | |
| - | + | *[[Proteasome 3D structures|Proteasome 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Borek | + | [[Category: Large Structures]] |
| - | [[Category: Jankowska | + | [[Category: Saccharomyces cerevisiae S288C]] |
| - | [[Category: | + | [[Category: Borek D]] |
| - | [[Category: Rostankowski | + | [[Category: Jankowska E]] |
| - | [[Category: | + | [[Category: Otwinowski Z]] |
| + | [[Category: Rostankowski R]] | ||
| + | [[Category: Witkowska J]] | ||
Current revision
Yeast 20S proteasome in complex with PR-VI modulator
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