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Current revision (19:17, 5 October 2015) (edit) (undo)
 
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==HIV Protease Inhibitor ==
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Ć==HIV Protease Inhibitor ==
<StructureSection load='3O99' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='3O99' size='340' side='right' caption='Caption for this structure' scene=''>
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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This article describes the crystallization of HIV Protease with various inhibitors including the K13 inhibitor shown in this structure. <ref>http://dx.doi.org/10.1016/j.chembiol.2013.07.014</ref>
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== Function ==
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Here I have highlighted key nonpolar residues in the <scene name='71/713483/Active_site_zoom/1'>active site</scene> that make van der Waals interactions with K13. The inhibitor has a longer hydrophobic region so it binds tighter here.
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[[Image:MW_Folding_Simulations.gif]]
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Here is a space-filling representation with <scene name='71/713483/Active_site_surface_hydrophobi/1'>polar and nonpolar coloring .</scene>
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<scene name='71/713483/Rainbow/1'>scene</scene>
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{{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}
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{{STRUCTURE_3O99 | PDB=3O99}}
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

Ć==HIV Protease Inhibitor ==

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. http://dx.doi.org/10.1016/j.chembiol.2013.07.014
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