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| - | {{STRUCTURE_1mwp| PDB=1mwp | SIZE=400| SCENE= |right| CAPTION=Human amyloid precursor protein heparin-binding domain [[1mwp]] }}
| + | <StructureSection load='1mwp' size='350' side='right' scene='45/455464/Cv/1' caption='Human amyloid precursor protein heparin-binding domain [[1mwp]]'> |
| | | | |
| | == Function == | | == Function == |
| | | | |
| - | '''Amyloid precursor protein''' (APP) is a transmembranal protein which is thought to regulate transcription. APP plays a role in synaptic formation and repair. | + | '''Amyloid precursor protein''' (APP) is a transmembranal protein which is thought to regulate transcription. APP plays a role in synaptic formation and repair.<ref>PMID:12927332</ref> |
| | | | |
| | == Disease == | | == Disease == |
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| | * [[Human APP]]<br /> | | * [[Human APP]]<br /> |
| | * [[Human APP Intracellular Domain Complex with Fe65-PTB2]]<br /> | | * [[Human APP Intracellular Domain Complex with Fe65-PTB2]]<br /> |
| - | * [[Amyloid beta]]. | + | * [[Beta Amyloid forms Plaques]]<br /> |
| | + | * [[Amyloid beta]] |
| | | | |
| | == Structural highlights == | | == Structural highlights == |
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| | | | |
| | ==3D structures of amyloid precursor protein== | | ==3D structures of amyloid precursor protein== |
| | + | [[Amyloid precursor protein 3D structures]] |
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| + | </StructureSection> |
| - | {{#tree:id=OrganizedByTopic|openlevels=0|
| + | |
| | | | |
| - | *APP
| + | == References == |
| - | | + | <references/> |
| - | **[[3nyj]], [[3nyl]], [[3umh]], [[3umi]], [[3umk]] – hAPP E2 domain – human<BR />
| + | |
| - | **[[3ktm]] – hAPP residues 18-190<BR />
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| - | **[[1ze7]], [[2bp4]] – hAPP zinc-binding domain – NMR<BR />
| + | |
| - | **[[2fjz]], [[2fma]] - hAPP residues 133-189<BR />
| + | |
| - | **[[1owt]] - hAPP residues 133-189 - NMR<BR />
| + | |
| - | **[[1rw6]] - hAPP residues 346-551<BR />
| + | |
| - | **[[1tkn]] - hAPP residues 460-569 - NMR<BR />
| + | |
| - | **[[1mwp]] - hAPP heparin-binding domain<br />
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| - | | + | |
| - | *hAPP β-peptide
| + | |
| - | | + | |
| - | **[[1z0q]], [[2beg]] – hAPP β-peptide residues 1-42 – NMR<br />
| + | |
| - | **[[1amb]], [[1amc]] – hAPP β-peptide residues 1-28 – NMR<br />
| + | |
| - | **[[1qcm]], [[1qyt]], [[1qwp]], [[1qxc]] – hAPP β-peptide residues 25-35 – NMR<br />
| + | |
| - | **[[1ba4]], [[1ba6]], [[2lnq]] – hAPP β-peptide residues 1-40 – NMR<br />
| + | |
| - | **[[1bjb]], [[1bjc]] – hAPP β-peptide residues 1-28 (mutant) – NMR<br />
| + | |
| - | **[[1nmj]] – APP β-peptide residues 1-28 – rat – NMR<br />
| + | |
| - | **[[3bae]] – hAPP β-peptide residues 1-28 + antibody<br />
| + | |
| - | **[[3bkj]] – hAPP β-peptide residues 1-16 + antibody<br />
| + | |
| - | **[[2roz]] – hAPP β-peptide residues 1-32 + amyloid β A4 precursor protein - NMR<br />
| + | |
| - | **[[2wk3]] – hAPP β-peptide residues 1-42 + insulin-degrading enzyme<br />
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| - | | + | |
| - | *Amyloid precursor protein binary complex
| + | |
| - | | + | |
| - | **[[1ze9]] - hAPP zinc-binding domain + Zn – NMR<BR />
| + | |
| - | **[[2fk1]], [[2fk2]], [[2fk3]], [[2fkl]] - hAPP residues 133-189 + Cu<BR />
| + | |
| - | **[[3jti]], [[3gci]] – hAPP peptide residues 699-706 + phospholipase A2<BR />
| + | |
| - | **[[3l81]] - hAPP peptide residues 761-767 + AP-4 complex subunit μ-1<BR />
| + | |
| - | **[[3ifl]], [[3ifn]], [[3ifo]], [[3ifp]], [[2r0w]] - hAPP peptide residues 672-711 + antibody<BR />
| + | |
| - | **[[2wk3]] - hAPP residues 672-713 + insulin degrading enzyme<BR />
| + | |
| - | **[[3dxc]] - hAPP residues 739-770 + Fe65-PTB2<BR />
| + | |
| - | **[[3dxd]], [[3dxe]] - hAPP residues 739-770 (mutant) + Fe65-PTB2<BR />
| + | |
| - | **[[2roz]] - hAPP peptide residues 582-704 + Fe65 C terminal<BR />
| + | |
| - | **[[2otk]] - hAPP residues 672-711 + ZAB3 affibody dimer - NMR<BR />
| + | |
| - | **[[3l3t]] - hAPP residues 211-267 + mesotrypsin<br />
| + | |
| - | **[[3l33]] - hAPP residues 290-341 + trypsin-3 (mutant)
| + | |
| - | }}
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| | [[Category:Topic Page]] | | [[Category:Topic Page]] |
