5epo
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The three-dimensional structure of Clostridium absonum 7alpha-hydroxysteroid dehydrogenase== |
| + | <StructureSection load='5epo' size='340' side='right'caption='[[5epo]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5epo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_sardiniense Clostridium sardiniense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EPO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TUD:TAUROCHENODEOXYCHOLIC+ACID'>TUD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5epo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epo OCA], [https://pdbe.org/5epo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5epo RCSB], [https://www.ebi.ac.uk/pdbsum/5epo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5epo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HDHA_CLOSR HDHA_CLOSR] 7alpha-hydroxysteroid dehydrogenase that catalyzes the NADP(+)-dependent oxidation of the 7alpha-hydroxy group of 7alpha-hydroxysteroids, such as cholate, chenodeoxycholate, glycochenodeoxycholate and taurochenodeoxycholate, to the corresponding 7-oxosteroids (PubMed:22198717, PubMed:24810359). Is also able to catalyze the reverse reduction reactions (PubMed:22198717). Together with 7beta-HSDH encoded in the adjacent gene, is likely involved in the epimerization of the hydroxy group at C-7 of primary bile acids through 7-keto bile acid intermediates (PubMed:22198717).<ref>PMID:22198717</ref> <ref>PMID:24810359</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Wang | + | [[Category: Clostridium sardiniense]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lou D]] | ||
| + | [[Category: Wang B]] | ||
| + | [[Category: Wang F]] | ||
Current revision
The three-dimensional structure of Clostridium absonum 7alpha-hydroxysteroid dehydrogenase
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