Cardiotoxin

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== Function ==
== Function ==
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[[Cardiotoxin]] (CTX) is a snake toxin from the Taiwan cobra ''Naja naja''. The cardiotoxin from the Malayan krait is called '''bucain'''. CTX perturb the membrane structure of cells by interaction with lipids. <ref>PMID:3472200</ref> For toxins in Proteopedia see [[Toxins]].<br />
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'''Cardiotoxin''' or '''cytotoxin''' (CTX) is a snake toxin from the Taiwan cobra ''Naja naja''. The cardiotoxin from the Malayan krait is called '''bucain'''. CTX perturb the membrane structure of cells by interaction with lipids. <ref>PMID:3472200</ref> For toxins in Proteopedia see [[Toxins]].<br />
== Relevance ==
== Relevance ==
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'''Cardiotoxin I''' causes necrosis of skeletal muscle cells.
'''Cardiotoxin I''' causes necrosis of skeletal muscle cells.
'''Cardiotoxin III''' induces apoptosis in K562 cells.
'''Cardiotoxin III''' induces apoptosis in K562 cells.
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</StructureSection>
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== 3D Structures of Cardiotoxin ==
== 3D Structures of Cardiotoxin ==
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[[Cardiotoxin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[2cdx]] - NaCTX I – NMR – ''Naja atra''<br />
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[[4om4]] - NaCTX II<br />
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[[1cre]], [[1crf]] - NaCTX II – NMR<br />
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[[2ccx]] – NmCTX II – ''Naja mossambica'' – NMR<br />
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[[1cdt]] – NmCTX II<br />
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[[1ffj]], [[1cb9]], [[1ccq]] – CTX II – ''Naja oxiana'' – NMR<br />
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[[1i02]], [[2crs]], [[2crt]] - NaCTX III – NMR<br />
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[[1xt3]], [[1h0j]] – NaCTX III<br />
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[[4om5]] - NaCTX IV<br />
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[[1kbs]], [[1kbt]] - NaCTX IV – NMR<br />
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[[1chv]], [[1cvo]] – NaCTX V – NMR<br />
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[[1kxi]] - NaCTX V<br />
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[[1ug4]] – CTX VI<br />
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[[3plc]] – β-CTX – king cobra<br />
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[[1cxn]], [[1cxo]], [[1tgx]] – γ-CTX – ''Naja nigricollis'' - NMR<br />
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[[2h8u]] – Bucain<br />
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[[2bhi]] – CTX III+sulfogalactoceramide<br />
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== References ==
== References ==

Current revision

Cardiotoxin CTX I 2cdx

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References

  1. ↑ Rees B, Samama JP, Thierry JC, Gilibert M, Fischer J, Schweitz H, Lazdunski M, Moras D. Crystal structure of a snake venom cardiotoxin. Proc Natl Acad Sci U S A. 1987 May;84(10):3132-6. PMID:3472200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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