Fibrin

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== Structural highlights ==
== Structural highlights ==
-
<scene name='41/417472/Cv/4'>Ca coordination site in β subunit</scene>.
+
<scene name='41/417472/Cv/6'>Ca coordination site in β subunit</scene>.
-
<scene name='41/417472/Cv/5'>Ca coordination site in γ subunit</scene> (PDB entry [[1n73]]).
+
<scene name='41/417472/Cv/7'>Ca coordination site in γ subunit</scene> (PDB entry [[1n73]]).
</StructureSection>
</StructureSection>
== 3D Structures of Fibrin ==
== 3D Structures of Fibrin ==
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[[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br />
[[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br />
[[1n8e]] - hFIa α, β, γ chains <br />
[[1n8e]] - hFIa α, β, γ chains <br />
-
[[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br />
+
[[2a45]] - hFIa α, β, γ chains + thrombin<br />
[[1fzc]] – hDDFIa+peptide<br />
[[1fzc]] – hDDFIa+peptide<br />
 +
[[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br />
== References ==
== References ==

Current revision

Fibrin α1 subunit (red, yellow), β subunit (cyan, blue), γ subunit (orange, magenta) from Petromyzon marinus (PDB entry 1n73)

Drag the structure with the mouse to rotate

3D Structures of Fibrin

Updated on 02-March-2023

3h32 – hFIa peptide+ hFI α, β, γ chains – human
2q9i, 2z4e - hFIa B-knob+ hFI α, β, γ chains
2hlo, 1n86 - hFIa α, β, γ chains + peptide
1n8e - hFIa α, β, γ chains
2a45 - hFIa α, β, γ chains + thrombin
1fzc – hDDFIa+peptide
1n73 - FIa α, β, γ chains + peptide – Sea lamprey

References

  1. Yang Z, Pandi L, Doolittle RF. The crystal structure of fragment double-D from cross-linked lamprey fibrin reveals isopeptide linkages across an unexpected D-D interface. Biochemistry. 2002 Dec 31;41(52):15610-7. PMID:12501189

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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