5lf0
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human 20S proteasome complex with Epoxomicin at 2.4 Angstrom== | |
| + | <StructureSection load='5lf0' size='340' side='right'caption='[[5lf0]], [[Resolution|resolution]] 2.41Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5lf0]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LF0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=6V1:(2~{R})-2-AZANYL-3-[(3~{R})-1-ETHYL-2,5-BIS(OXIDANYLIDENE)PYRROLIDIN-3-YL]SULFANYL-PROPANOIC+ACID'>6V1</scene>, <scene name='pdbligand=6VO:(3~{R},4~{S})-4-AZANYL-2,6-DIMETHYL-HEPTANE-2,3-DIOL'>6VO</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IML:N-METHYL-ISOLEUCINE'>IML</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lf0 OCA], [https://pdbe.org/5lf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lf0 RCSB], [https://www.ebi.ac.uk/pdbsum/5lf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lf0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSA4_HUMAN PSA4_HUMAN] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. | ||
| - | + | ==See Also== | |
| - | + | *[[Proteasome 3D structures|Proteasome 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Bourenkov G]] | ||
| + | [[Category: Chari A]] | ||
| + | [[Category: Henneberg F]] | ||
| + | [[Category: Mata R]] | ||
| + | [[Category: Schneider TR]] | ||
| + | [[Category: Schrader J]] | ||
| + | [[Category: Stark H]] | ||
| + | [[Category: Tittmann K]] | ||
Current revision
Human 20S proteasome complex with Epoxomicin at 2.4 Angstrom
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