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5gjq

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'''Unreleased structure'''
 
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The entry 5gjq is ON HOLD
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==Structure of the human 26S proteasome bound to USP14-UbAl==
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<SX load='5gjq' size='340' side='right' viewer='molstar' caption='[[5gjq]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5gjq]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GJQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GLZ:AMINO-ACETALDEHYDE'>GLZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gjq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gjq OCA], [https://pdbe.org/5gjq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gjq RCSB], [https://www.ebi.ac.uk/pdbsum/5gjq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gjq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSB6_HUMAN PSB6_HUMAN] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the cryo-EM structure of the human 26S proteasome at an average resolution of 3.5 A, allowing atomic modeling of 28 subunits in the core particle (CP) and 18 subunits in the regulatory particle (RP). The C-terminal residues of Rpt3 and Rpt5 subunits in the RP can be seen inserted into surface pockets formed between adjacent alpha subunits in the CP. Each of the six Rpt subunits contains a bound nucleotide, and the central gate of the CP alpha-ring is closed despite RP association. The six pore 1 loops in the Rpt ring are arranged similarly to a spiral staircase along the axial channel of substrate transport, which is constricted by the pore 2 loops. We also determined the cryo-EM structure of the human proteasome bound to the deubiquitinating enzyme USP14 at 4.35-A resolution. Together, our structures provide a framework for mechanistic understanding of eukaryotic proteasome function.
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Authors: Huang, X.L., Luan, B., Wu, J.P., Shi, Y.G.
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An atomic structure of the human 26S proteasome.,Huang X, Luan B, Wu J, Shi Y Nat Struct Mol Biol. 2016 Jul 18. doi: 10.1038/nsmb.3273. PMID:27428775<ref>PMID:27428775</ref>
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Description: Structure of the human 26S proteasome bound to USP14-UbAl
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Shi, Y.G]]
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<div class="pdbe-citations 5gjq" style="background-color:#fffaf0;"></div>
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[[Category: Wu, J.P]]
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[[Category: Luan, B]]
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==See Also==
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[[Category: Huang, X.L]]
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang XL]]
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[[Category: Luan B]]
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[[Category: Shi YG]]
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[[Category: Wu JP]]

Current revision

Structure of the human 26S proteasome bound to USP14-UbAl

5gjq, resolution 4.50Å

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OCA

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