5t0h
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Structural basis for dynamic regulation of the human 26S proteasome== | |
+ | <SX load='5t0h' size='340' side='right' viewer='molstar' caption='[[5t0h]], [[Resolution|resolution]] 6.80Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[5t0h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T0H FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.8Å</td></tr> | ||
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t0h OCA], [https://pdbe.org/5t0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t0h RCSB], [https://www.ebi.ac.uk/pdbsum/5t0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t0h ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/PRS7_HUMAN PRS7_HUMAN] The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.<ref>PMID:9295362</ref> | ||
- | + | ==See Also== | |
- | + | *[[Proteasome 3D structures|Proteasome 3D structures]] | |
- | + | == References == | |
- | [[Category: | + | <references/> |
- | [[Category: | + | __TOC__ |
- | [[Category: | + | </SX> |
- | [[Category: | + | [[Category: Homo sapiens]] |
- | [[Category: | + | [[Category: Large Structures]] |
- | [[Category: | + | [[Category: Chen S]] |
- | [[Category: Ma | + | [[Category: Finley D]] |
- | [[Category: | + | [[Category: Kirschner MW]] |
- | [[Category: | + | [[Category: Lee BH]] |
- | [[Category: Wu | + | [[Category: Lu Y]] |
- | [[Category: | + | [[Category: Ma YB]] |
+ | [[Category: Mao Y]] | ||
+ | [[Category: Ouyang Q]] | ||
+ | [[Category: Wu J]] | ||
+ | [[Category: Yu Z]] |
Current revision
Structural basis for dynamic regulation of the human 26S proteasome
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Categories: Homo sapiens | Large Structures | Chen S | Finley D | Kirschner MW | Lee BH | Lu Y | Ma YB | Mao Y | Ouyang Q | Wu J | Yu Z