This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5t0j
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5t0j is ON HOLD Authors: Chen, S., Wu, J., Lu, Y., Ma, Y.B., Lee, B.H., Yu, Z., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y. Description: Struc...) |
|||
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis for dynamic regulation of the human 26S proteasome== | |
| + | <SX load='5t0j' size='340' side='right' viewer='molstar' caption='[[5t0j]], [[Resolution|resolution]] 8.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5t0j]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T0J FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t0j OCA], [https://pdbe.org/5t0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t0j RCSB], [https://www.ebi.ac.uk/pdbsum/5t0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t0j ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSMD2_HUMAN PSMD2_HUMAN] Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. | ||
| - | + | ==See Also== | |
| - | + | *[[Proteasome 3D structures|Proteasome 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </SX> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chen S]] |
| - | [[Category: | + | [[Category: Finley D]] |
| - | [[Category: | + | [[Category: Kirschner MW]] |
| - | [[Category: Ma | + | [[Category: Lee BH]] |
| - | [[Category: | + | [[Category: Lu Y]] |
| - | [[Category: | + | [[Category: Ma YB]] |
| - | [[Category: Wu | + | [[Category: Mao Y]] |
| - | [[Category: | + | [[Category: Ouyang Q]] |
| + | [[Category: Wu J]] | ||
| + | [[Category: Yu Z]] | ||
Current revision
Structural basis for dynamic regulation of the human 26S proteasome
| |||||||||
Categories: Homo sapiens | Large Structures | Chen S | Finley D | Kirschner MW | Lee BH | Lu Y | Ma YB | Mao Y | Ouyang Q | Wu J | Yu Z
