This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5tho

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:01, 4 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with N,C-capped Dipeptide Inhibitor PKS2205==
==Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with N,C-capped Dipeptide Inhibitor PKS2205==
-
<StructureSection load='5tho' size='340' side='right' caption='[[5tho]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+
<StructureSection load='5tho' size='340' side='right'caption='[[5tho]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5tho]] is a 28 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5THO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5THO FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5tho]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5THO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5THO FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7C7:N,N-DIETHYL-N~2~-(3-PHENYLPROPANOYL)-L-ASPARAGINYL-O-METHYL-N-[(NAPHTHALEN-1-YL)METHYL]-L-SERINAMIDE'>7C7</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.002&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7C7:N,N-DIETHYL-N~2~-(3-PHENYLPROPANOYL)-L-ASPARAGINYL-O-METHYL-N-[(NAPHTHALEN-1-YL)METHYL]-L-SERINAMIDE'>7C7</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tho OCA], [http://pdbe.org/5tho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tho RCSB], [http://www.ebi.ac.uk/pdbsum/5tho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tho ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tho OCA], [https://pdbe.org/5tho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tho RCSB], [https://www.ebi.ac.uk/pdbsum/5tho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tho ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PSA_MYCTA PSA_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. [[http://www.uniprot.org/uniprot/PSB_MYCTA PSB_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
+
[https://www.uniprot.org/uniprot/PSA_MYCTA PSA_MYCTA] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5tho" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5tho" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Proteasome 3D structures|Proteasome 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Proteasome endopeptidase complex]]
+
[[Category: Large Structures]]
-
[[Category: Hsu, H C]]
+
[[Category: Mycobacterium tuberculosis H37Ra]]
-
[[Category: Li, H]]
+
[[Category: Hsu HC]]
-
[[Category: Dipeptide inhibitor]]
+
[[Category: Li H]]
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Mycobacterium tuberculosis]]
+
-
[[Category: Proteasome]]
+

Current revision

Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with N,C-capped Dipeptide Inhibitor PKS2205

PDB ID 5tho

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5tho"
Personal tools