Rac GTPase-activating protein

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(New page: <StructureSection load='5c2j' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Rac GTPase-activating protein 1''' (RACGAP1) is required for the at...)
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<StructureSection load='5c2j' size='340' side='right' caption='Human Rac GTPase-activating protein 1 GAP domain (grey) complex with CDC42 (green) and GDP (PDB code [[5c2j]])' scene=''>
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<StructureSection load='5c2j' size='340' side='right' caption='Caption for this structure' scene=''>
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== Function ==
== Function ==
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'''Rac GTPase-activating protein 1''' (RACGAP1) is required for the attachment of the midbody to the cell membrane during cytokinesis. It is involved in the regulation of growth-related processes in adipocytes and myoblasts.
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'''Rac GTPase-activating protein 1''' (RacGAP1) is required for the attachment of the midbody to the cell membrane during cytokinesis. It is involved in the regulation of growth-related processes in adipocytes and myoblasts.
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== Disease ==
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== Relevance ==
== Relevance ==
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RACGAP1 expression is a prognostic marker for HBV-positive human hepatocellular carcinoma and can be a potential molecular target for therapeutic strategies against this carcinoma<ref>PMID:21825042</ref>.
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RacGAP1 expression is a prognostic marker for HBV-positive human hepatocellular carcinoma and can be a potential molecular target for therapeutic strategies against this carcinoma<ref>PMID:21825042</ref>.
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== Structural highlights ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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**[[3w6r]], [[2ovj]] – hRacGAP GAP domain – human<br />
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[[3w6r]], [[2ovj]] – hRacGAP GAP domain – human<br />
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**[[3wpq]], [[3wps]] – hRacGAP GAP domain (mutant) <br />
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[[3wpq]], [[3wps]] – hRacGAP GAP domain (mutant) <br />
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**[[4b6d]] – hRacGAP C1 domain <br />
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[[4b6d]] – hRacGAP C1 domain <br />
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**[[5c2j]] – hRacGAP GAP domain + CDC42 + GDP <br />
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[[5c2j]] – hRacGAP GAP domain + CDC42 + GDP <br />
== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

Human Rac GTPase-activating protein 1 GAP domain (grey) complex with CDC42 (green) and GDP (PDB code 5c2j)

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3D structures of Rac GTPase-activating protein 1

Updated on 23-October-2017

3w6r, 2ovj – hRacGAP GAP domain – human
3wpq, 3wps – hRacGAP GAP domain (mutant)
4b6d – hRacGAP C1 domain
5c2j – hRacGAP GAP domain + CDC42 + GDP

References

  1. ↑ Wang SM, Ooi LL, Hui KM. Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma. Clin Cancer Res. 2011 Sep 15;17(18):6040-51. doi: 10.1158/1078-0432.CCR-11-0557. , Epub 2011 Aug 8. PMID:21825042 doi:http://dx.doi.org/10.1158/1078-0432.CCR-11-0557

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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