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5x1e

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'''Unreleased structure'''
 
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The entry 5x1e is ON HOLD until Paper Publication
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==Structure of DotL(656-783)-IcmS-IcmW derived from Legionella pneumophila==
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<StructureSection load='5x1e' size='340' side='right'caption='[[5x1e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5x1e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X1E FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.999&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x1e OCA], [https://pdbe.org/5x1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x1e RCSB], [https://www.ebi.ac.uk/pdbsum/5x1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x1e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ICMS_LEGPH ICMS_LEGPH] Component of the Dot/Icm type IVB secretion system (T4BSS), which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:15661013, PubMed:18069892, PubMed:17040490, PubMed:22694730, PubMed:32513920). Part of a subcomplex which recruits effector proteins and delivers them to the core transmembrane subcomplex (PubMed:23028312, PubMed:32513920). The IcmS/IcmW protein complex plays an important role in protein translocation by interacting with multiple Dot/Icm effector proteins to facilitate their translocation into host cells (PubMed:15661013, PubMed:18069892). Interaction promotes conformational changes in the effector protein, which may facilitate display of a C-terminal translocation signal (PubMed:18069892). May maintain the substrates in a translocation competent form (PubMed:23028312). Required for intracellular growth in host cells, replicative phagosome formation and phagosome trafficking (PubMed:11115108). IcmS is required for IcmW stability (PubMed:15661013, PubMed:29203674).<ref>PMID:11115108</ref> <ref>PMID:15661013</ref> <ref>PMID:17040490</ref> <ref>PMID:18069892</ref> <ref>PMID:22694730</ref> <ref>PMID:23028312</ref> <ref>PMID:29203674</ref> <ref>PMID:32513920</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
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[[Category: Kim JD]]
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[[Category: Kwak MJ]]
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[[Category: Oh BH]]

Current revision

Structure of DotL(656-783)-IcmS-IcmW derived from Legionella pneumophila

PDB ID 5x1e

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