5uqd

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Current revision (14:28, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5uqd is ON HOLD until Paper Publication
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==DPY-21 in complex with Fe(II) and alpha-Ketoglutarate==
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<StructureSection load='5uqd' size='340' side='right'caption='[[5uqd]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5uqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UQD FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.798&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uqd OCA], [https://pdbe.org/5uqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uqd RCSB], [https://www.ebi.ac.uk/pdbsum/5uqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uqd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPY21_CAEEL DPY21_CAEEL] Required for X chromosome dosage compensation by reducing X-linked gene transcription in hermaphrodites throughout development (PubMed:14660541, PubMed:23028348, PubMed:3779843, PubMed:3478715, PubMed:26641248, PubMed:22393255). Might be involved in the regulation of histone H4 post-translational modifications on the X chromosome leading to transcriptional repression of X-linked genes (PubMed:22393255, PubMed:23028348, PubMed:26641248). Involved in the regulation of growth, fecundity and body fat metabolism downstream of the TOR complex 2 and the protein kinase sgk-1 pathway (PubMed:23884442). Also involved in male tail development (PubMed:6537930).<ref>PMID:14660541</ref> <ref>PMID:22393255</ref> <ref>PMID:23028348</ref> <ref>PMID:23884442</ref> <ref>PMID:26641248</ref> <ref>PMID:3478715</ref> <ref>PMID:3779843</ref> <ref>PMID:6537930</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Caenorhabditis elegans]]
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[[Category: Large Structures]]
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[[Category: Anderson EC]]
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[[Category: Bian Q]]
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[[Category: Brejc K]]
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[[Category: King DS]]
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[[Category: Kranzusch PJ]]
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[[Category: Meyer BJ]]
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[[Category: Preston CG]]
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[[Category: Uzawa S]]
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[[Category: Wheeler BS]]

Current revision

DPY-21 in complex with Fe(II) and alpha-Ketoglutarate

PDB ID 5uqd

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