2n3m
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==G-quadruplex structure of an anti-proliferative DNA sequence== | ==G-quadruplex structure of an anti-proliferative DNA sequence== | ||
| - | <StructureSection load='2n3m' size='340' side='right' caption='[[2n3m | + | <StructureSection load='2n3m' size='340' side='right'caption='[[2n3m]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2n3m]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3M OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[2n3m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N3M FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n3m OCA], [https://pdbe.org/2n3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n3m RCSB], [https://www.ebi.ac.uk/pdbsum/2n3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n3m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | AGRO100 (also known as AS1411) is a G-rich oligonucleotide that has long been established as a potent anti-cancer aptamer. However, the structure of AGRO100 remained unresolved, due to the co-existence of multiple different G-quadruplex conformations. We identified a DNA sequence named AT11, derived from AGRO100, which formed a single major G-quadruplex conformation and exhibited a similar anti-proliferative activity as AGRO100. The solution structure of AT11 revealed a four-layer G-quadruplex comprising of two propeller-type parallel-stranded subunits connected through a central linker. The stacking between the two subunits occurs at the 3Î-end of the first block and the 5Î-end of the second block. The structure of the anti-proliferative DNA sequence AT11 will allow greater understanding on the G-quadruplex folding principles and aid in structural optimization of anti-proliferative oligonucleotides. | ||
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| + | G-quadruplex structure of an anti-proliferative DNA sequence.,Do NQ, Chung WJ, Truong THA, Heddi B, Phan AT Nucleic Acids Res. 2017 Jul 7;45(12):7487-7493. doi: 10.1093/nar/gkx274. PMID:28549181<ref>PMID:28549181</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2n3m" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Chung WJ]] |
| - | [[Category: | + | [[Category: Do NQ]] |
| - | [[Category: | + | [[Category: Heddi B]] |
| - | [[Category: | + | [[Category: Phan AT]] |
| - | [[Category: | + | [[Category: Truong THA]] |
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Current revision
G-quadruplex structure of an anti-proliferative DNA sequence
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