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5w5c

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==Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2AB complex==
==Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2AB complex==
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<StructureSection load='5w5c' size='340' side='right' caption='[[5w5c]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='5w5c' size='340' side='right'caption='[[5w5c]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5w5c]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W5C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5w5c]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W5C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w5c OCA], [http://pdbe.org/5w5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w5c RCSB], [http://www.ebi.ac.uk/pdbsum/5w5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w5c ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w5c OCA], [https://pdbe.org/5w5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w5c RCSB], [https://www.ebi.ac.uk/pdbsum/5w5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w5c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. [[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT]] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [[http://www.uniprot.org/uniprot/CPLX1_RAT CPLX1_RAT]] Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).
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[https://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5w5c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5w5c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Complexin|Complexin]]
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*[[Synaptosomal-associated protein|Synaptosomal-associated protein]]
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*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
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*[[Syntaxin 3D structures|Syntaxin 3D structures]]
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*[[Vesicle-associated membrane protein|Vesicle-associated membrane protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brunger, A T]]
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[[Category: Large Structures]]
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[[Category: Zhou, Q]]
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[[Category: Rattus norvegicus]]
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[[Category: Complexin]]
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[[Category: Brunger AT]]
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[[Category: Exocytosis]]
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[[Category: Zhou Q]]
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[[Category: Neuronal exocytosis]]
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[[Category: Prefusion primed complex]]
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[[Category: Snare complex]]
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[[Category: Synaptotagmin]]
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[[Category: Synchronous neurotransmitter release]]
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Current revision

Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2AB complex

PDB ID 5w5c

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