This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Platelet glycoprotein
From Proteopedia
(Difference between revisions)
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' scene='1m10/Surface/2' caption='Platelet-receptor glycoprotein Ib alpha (blue) involved in Willebrand disease bound to the von Willebrand Factor A1 Domain (green surface), ([[1m10]])' > |
{{Clear}} | {{Clear}} | ||
| Line 13: | Line 13: | ||
[[1m10]] is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M10 OCA]. | [[1m10]] is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M10 OCA]. | ||
| + | |||
| + | ==Platelet glycoprotein 4 == | ||
| + | |||
| + | '''Platelet glycoprotein 4''' or '''CD36''' functions as a receptor for thrombospondin and collagen <ref>PMID:2665870</ref>. | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of platelet glycoprotein | + | ==3D structures of platelet glycoprotein== |
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| Line 21: | Line 25: | ||
*Platelet glycoprotein Ib | *Platelet glycoprotein Ib | ||
| - | **[[1m0z]] – hPGIb von Willenbrand factor binding domain (mutant) | + | **[[1gwb]], [[1p9a]], [[1qyy]] – hPGIb von Willenbrand factor binding domain 17-306 - human <BR /> |
| - | **[[ | + | **[[1m0z]] – hPGIb von Willenbrand factor binding domain (mutant) <BR /> |
| + | **[[3rfe]] – hPGIb b chain 26-146<BR /> | ||
| + | **[[3rfe]] – hPGIb b chain 26-146 (mutant)<BR /> | ||
| + | **[[6ejx]] – PGIb a chain von Willenbrand factor binding domain - mouse<BR /> | ||
*Platelet glycoprotein Ib complexes | *Platelet glycoprotein Ib complexes | ||
**[[1m10]], [[1sq0]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain (mutant)<BR /> | **[[1m10]], [[1sq0]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain (mutant)<BR /> | ||
| + | **[[6xfq]] – hPGIb von Willenbrand factor binding domain + agkisacucetin<BR /> | ||
**[[1u0n]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain + botrocetin<BR /> | **[[1u0n]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain + botrocetin<BR /> | ||
| - | **[[1gwb]] – hPGIb | + | **[[3pmh]], [[1gwb]] – hPGIb von Willenbrand factor binding domain (mutant) + thrombin<BR /> |
**[[1p8v]] – hPGIb von Willenbrand factor binding domain (mutant) + prothrombin<BR /> | **[[1p8v]] – hPGIb von Willenbrand factor binding domain (mutant) + prothrombin<BR /> | ||
| - | **[[3pmh]] – hPGIb von Willenbrand factor binding domain (mutant) + thrombin<BR /> | ||
| - | **[[2bp3]] – hPGIb cytoplasmic domain + filamin A rod domain <BR /> | ||
**[[1sq0]] – hPGIb von Willenbrand factor binding domain + peptide inhibitor<BR /> | **[[1sq0]] – hPGIb von Willenbrand factor binding domain + peptide inhibitor<BR /> | ||
| + | **[[2bp3]] – hPGIb cytoplasmic domain + filamin A rod domain <BR /> | ||
| + | **[[1ook]] – hPGIb a chain + alpha thrombin + peptide<BR /> | ||
| + | **[[4c2a]], [[4c2b]] – hPGIb a chain (mutant) + von Willenbrand factor <BR /> | ||
| + | **[[3p72]] – hPGIb a chain + peptide inhibitor<BR /> | ||
| + | |||
| + | *Platelet glycoprotein 4 | ||
| + | |||
| + | **[[5lgd]] – hPG4 + PFEMP1 <BR /> | ||
| + | |||
| + | *Platelet glycoprotein 6 | ||
| + | |||
| + | **[[2gi7]], [5ou7]] – hPG6 <BR /> | ||
| + | **[[5ou9]], [[5ou8]] – hPG6 + collagen peptide <BR /> | ||
| + | **[[7nmu]] – hPG6 + nanobody <BR /> | ||
| + | **[[7r58]] – hPG6 + antibody <BR /> | ||
}} | }} | ||
Current revision
| |||||||||||
3D structures of platelet glycoprotein
Updated on 03-September-2023
Reference
- Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science. 2002 Aug 16;297(5584):1176-9. PMID:12183630 doi:10.1126/science.107355
See Also
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Wayne Decatur, Jaime Prilusky

