4grv

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==The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13)==
==The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13)==
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<StructureSection load='4grv' size='340' side='right' caption='[[4grv]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='4grv' size='340' side='right'caption='[[4grv]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4grv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GRV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4grv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GRV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.802&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ntsr1, Ntsr, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grv OCA], [http://pdbe.org/4grv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4grv RCSB], [http://www.ebi.ac.uk/pdbsum/4grv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4grv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4grv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4grv OCA], [https://pdbe.org/4grv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4grv RCSB], [https://www.ebi.ac.uk/pdbsum/4grv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4grv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NTR1_RAT NTR1_RAT]] Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
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[https://www.uniprot.org/uniprot/NTR1_RAT NTR1_RAT] Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Escherichia virus T4]]
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[[Category: Grisshammer, R]]
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[[Category: Large Structures]]
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[[Category: Gvozdenovic-Jeremic, J]]
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[[Category: Rattus norvegicus]]
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[[Category: Kloss, B]]
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[[Category: Grisshammer R]]
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[[Category: Love, J]]
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[[Category: Gvozdenovic-Jeremic J]]
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[[Category: Noinaj, N]]
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[[Category: Kloss B]]
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[[Category: Shah, P]]
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[[Category: Love J]]
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[[Category: Shibata, Y]]
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[[Category: Noinaj N]]
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[[Category: Shiloach, J]]
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[[Category: Shah P]]
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[[Category: Tate, C G]]
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[[Category: Shibata Y]]
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[[Category: White, J F]]
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[[Category: Shiloach J]]
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[[Category: Xu, F]]
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[[Category: Tate CG]]
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[[Category: G-protein]]
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[[Category: White JF]]
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[[Category: G-protein coupled receptor]]
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[[Category: Xu F]]
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[[Category: Neurotensin receptor]]
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[[Category: Signaling protein-agonist complex]]
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Current revision

The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13)

PDB ID 4grv

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