5yiy
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5yiy is ON HOLD Authors: Karade, S.S., Pratap, J.V. Description: Crystal structure of D175A mutant of Rv3272 from Mycobacterium tuberculosis [[Cate...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of D175A mutant of Rv3272 from Mycobacterium tuberculosis== | |
| - | + | <StructureSection load='5yiy' size='340' side='right'caption='[[5yiy]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yiy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YIY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yiy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yiy OCA], [https://pdbe.org/5yiy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yiy RCSB], [https://www.ebi.ac.uk/pdbsum/5yiy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yiy ProSAT]</span></td></tr> |
| - | [[Category: Karade | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/COATR_MYCTU COATR_MYCTU] Probably involved in fatty acid metabolism. Binds to fatty acyl-CoAs of varying carbon chain lengths, with the highest binding affinity for palmitoyl-CoA (C16:0). In vitro, alters the cell wall lipid profile and protects mycobacteria from acidic, oxidative and antibiotic stress. May play a significant role in host-pathogen interaction.<ref>PMID:30342240</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Karade SS]] | ||
| + | [[Category: Pratap JV]] | ||
Current revision
Crystal structure of D175A mutant of Rv3272 from Mycobacterium tuberculosis
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