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3log

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==Crystal structure of MbtI from Mycobacterium tuberculosis==
==Crystal structure of MbtI from Mycobacterium tuberculosis==
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<StructureSection load='3log' size='340' side='right' caption='[[3log]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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<StructureSection load='3log' size='340' side='right'caption='[[3log]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3log]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LOG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3log]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LOG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mbtI, MT2454, Rv2386c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3log FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3log OCA], [http://pdbe.org/3log PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3log RCSB], [http://www.ebi.ac.uk/pdbsum/3log PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3log ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3log FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3log OCA], [https://pdbe.org/3log PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3log RCSB], [https://www.ebi.ac.uk/pdbsum/3log PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3log ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU]] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref>
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[https://www.uniprot.org/uniprot/MBTI_MYCTU MBTI_MYCTU] Mediates the production of salicylate from chorismate via an isochorismate intermediate. Presents both isochorismate synthase and isochorismate-pyruvate lyase activities. Salycilate is the starter unit in the production of the virulence-conferring salicylate-based siderophore mycobactin.<ref>PMID:16923875</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3log" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3log" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Isochorismate pyruvate lyase|Isochorismate pyruvate lyase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker, E N]]
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[[Category: Large Structures]]
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[[Category: Bulloch, E M.M]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Johnston, J M]]
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[[Category: Baker EN]]
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[[Category: Lott, J S]]
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[[Category: Bulloch EMM]]
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[[Category: Anthranilate]]
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[[Category: Johnston JM]]
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[[Category: Chorismate]]
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[[Category: Lott JS]]
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[[Category: Ion transport]]
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[[Category: Isochorismate]]
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[[Category: Isochorismate lyase]]
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[[Category: Isochorismate synthase]]
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[[Category: Isomerase]]
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[[Category: Lyase]]
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[[Category: Metal-binding]]
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[[Category: Multifunctional enzyme]]
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[[Category: Salicylate]]
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[[Category: Transport]]
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Current revision

Crystal structure of MbtI from Mycobacterium tuberculosis

PDB ID 3log

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