1l8w

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==Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi==
==Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi==
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<StructureSection load='1l8w' size='340' side='right' caption='[[1l8w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='1l8w' size='340' side='right'caption='[[1l8w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1l8w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35210 Atcc 35210]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1L8W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1l8w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8W FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8w OCA], [http://pdbe.org/1l8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1l8w RCSB], [http://www.ebi.ac.uk/pdbsum/1l8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8w ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8w OCA], [https://pdbe.org/1l8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8w RCSB], [https://www.ebi.ac.uk/pdbsum/1l8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8w ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O06878_BORBG O06878_BORBG] The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time. Switching between these genes is a mechanism of host immune response evasion.[RuleBase:RU363105]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8w_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1l8w" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1l8w" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[==VlsE==|==VlsE==]]
 
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*[[SB2013 L04gr5|SB2013 L04gr5]]
 
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*[[StudioG24SecL04Tpc5|StudioG24SecL04Tpc5]]
 
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*[[User:Marvin O'Neal/VlsE|User:Marvin O'Neal/VlsE]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 35210]]
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[[Category: Borreliella burgdorferi]]
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[[Category: Eicken, C]]
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[[Category: Large Structures]]
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[[Category: Hardham, J M]]
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[[Category: Eicken C]]
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[[Category: Klabunde, T]]
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[[Category: Hardham JM]]
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[[Category: Lawrenz, M B]]
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[[Category: Klabunde T]]
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[[Category: Norris, S J]]
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[[Category: Lawrenz MB]]
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[[Category: Sacchettini, J C]]
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[[Category: Norris SJ]]
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[[Category: Sharma, V]]
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[[Category: Sacchettini JC]]
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[[Category: Immune system]]
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[[Category: Sharma V]]
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[[Category: Variable surface protein]]
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[[Category: Vmp-like sequence]]
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Current revision

Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi

PDB ID 1l8w

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