Adenosine A2A receptor
From Proteopedia
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== Relevance == | == Relevance == | ||
| - | A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by caffeine producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]]. | + | A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by <scene name='54/540144/5mzp_caffeine/1'>caffeine</scene> producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]]. |
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| + | See also: | ||
| + | * [[G protein-coupled receptor]] | ||
| + | *[[Receptor]] | ||
| + | *[[Transmembrane (cell surface) receptors]] | ||
== Structural highlights == | == Structural highlights == | ||
Like other G proteins, <scene name='54/540144/Cv/5'>A2AR has 7 transmembrane helices</scene>. | Like other G proteins, <scene name='54/540144/Cv/5'>A2AR has 7 transmembrane helices</scene>. | ||
| - | *<scene name='54/540144/Cv/8'>A2AR | + | *<scene name='54/540144/Cv/8'>A2AR has a ligand-binding cavity</scene>. |
*<scene name='54/540144/Cv/7'>Adenosine binding site</scene>. | *<scene name='54/540144/Cv/7'>Adenosine binding site</scene>. | ||
| - | </StructureSection> | ||
== 3D Structures of adenosine A2A receptor == | == 3D Structures of adenosine A2A receptor == | ||
| - | + | [[Adenosine A2A receptor 3D structures]] | |
| - | + | ||
| + | </StructureSection> | ||
| + | |||
| - | [[3eml]] – hA2AR/lysozyme + antagonist – human<br /> | ||
| - | [[5k2a]], [[5k2b]], [[5k2c]], [[5k2d]] – hA2AR/cytochrome b562 <br /> | ||
| - | [[5iu4]], [[5iu7]], [[5iu8]], [[5iua]], [[5iub]] – hA2AR/cytochrome b562 (mutant) + inhibitor<br /> | ||
| - | [[4ug2]], [[4uhr]] – hA2AR (mutant) + inhibitor<br /> | ||
| - | [[5g53]] – hA2AR + G protein <br /> | ||
| - | [[3qak]] – hA2AR/lysozyme + agonist <br /> | ||
| - | [[2ydo]] – hA2AR (mutant) + adenosine<br /> | ||
| - | [[2ydv]], [[5wf5]], [[5wf6]] – hA2AR (mutant) + agonist<br /> | ||
| - | [[3pwh]], [[3rey]], [[3rfm]], [[3uza]], [[3uzc]] – hA2AR (mutant) + antagonist<br /> | ||
| - | [[3rfm]] – hA2AR (mutant) + caffeine<br /> | ||
| - | [[3vg9]], [[3vga]] – hA2AR (mutant) + antibody<br /> | ||
| - | [[5jtb]], [[5nlx]], [[5nm2]], [[5nm4]], [[5uvi]], [[5vra]] – hA2AR/cytochrome b562 <br /> | ||
| - | [[5olg]], [[5olh]], [[5olo]], [[5olv]], [[5olz]], [[5om1]], [[5om4]] – hA2AR/cytochrome b562 (mutant) <br /> | ||
| - | [[4eiy]] – hA2AR/cytochrome b562 + antagonist <br /> | ||
| - | [[5uig]], [[6aqf]] – hA2AR/cytochrome b562 (mutant) + antagonist <br /> | ||
| - | [[5mzj]] – hA2AR/cytochrome b562 (mutant) + theophylline <br /> | ||
| - | [[5mzp]] – hA2AR/cytochrome b562 (mutant) + caffeine <br /> | ||
| - | [[5n2r]] – hA2AR/cytochrome b562 (mutant) + xanthine derivative <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG. Agonist-bound adenosine A(2A) receptor structures reveal common features of GPCR activation. Nature. 2011 May 18. PMID:21593763 doi:10.1038/nature10136
- ↑ Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J Neurosci. 2011 Jul 6;31(27):10067-75. doi: 10.1523/JNEUROSCI.6730-10.2011. PMID:21734299 doi:http://dx.doi.org/10.1523/JNEUROSCI.6730-10.2011
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