6gmc

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m (Protected "6gmc" [edit=sysop:move=sysop])
Current revision (06:02, 27 June 2018) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6gmc is ON HOLD
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==1.2 A resolution structure of human hydroxyacid oxidase 1 bound with FMN and 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole==
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<StructureSection load='6gmc' size='340' side='right' caption='[[6gmc]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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Authors: MacKinnon, S., Bezerra, G.A., Krojer, T., Smee, C., Arrowsmith, C.H., Edwards, E., Bountra, C., Oppermann, U., Brennan, P.E., Yue, W.W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6gmc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GMC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GMC FirstGlance]. <br>
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Description: 1.2 A resolution structure of human hydroxyacid oxidase 1 bound with FMN and 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C7C:5-[(4-CHLOROPHENYL)SULFANYL]-1,2,3-THIADIAZOLE-4-CARBOXYLATE'>C7C</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nzl|2nzl]], [[6gmb|6gmb]]</td></tr>
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[[Category: Smee, C]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HAO1, GOX1, HAOX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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[[Category: Yue, W.W]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(S)-2-hydroxy-acid_oxidase (S)-2-hydroxy-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.15 1.1.3.15] </span></td></tr>
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[[Category: Mackinnon, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gmc OCA], [http://pdbe.org/6gmc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gmc RCSB], [http://www.ebi.ac.uk/pdbsum/6gmc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gmc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN]] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bezerra, G A]]
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[[Category: Bountra, C]]
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[[Category: Brennan, P E]]
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[[Category: Edwards, E]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
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[[Category: Bountra, C]]
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[[Category: MacKinnon, S]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Oppermann, U]]
[[Category: Oppermann, U]]
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[[Category: Bezerra, G.A]]
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[[Category: Smee, C]]
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[[Category: Edwards, E]]
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[[Category: Yue, W W]]
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[[Category: Brennan, P.E]]
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[[Category: Fmn]]
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[[Category: Glycolate]]
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[[Category: Glyoxylate]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxisome]]
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[[Category: Primary hyperoxaluria]]

Current revision

1.2 A resolution structure of human hydroxyacid oxidase 1 bound with FMN and 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole

6gmc, resolution 1.20Å

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