6dte
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6dte is ON HOLD until Paper Publication Authors: Mark, B.L., Winogrodzki, J.L. Description: GlcNAc-inspired cyclophellitol bound to NagZ [[Category...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==GlcNAc-inspired cyclophellitol bound to NagZ== | |
| + | <StructureSection load='6dte' size='340' side='right'caption='[[6dte]], [[Resolution|resolution]] 1.93Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6dte]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_cenocepacia Burkholderia cenocepacia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DTE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.929Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H9J:2,2,2-tris(fluoranyl)-~{N}-[(2~{R},3~{R},5~{R},6~{R})-4-(hydroxymethyl)-2,3,5,6-tetrakis(oxidanyl)cyclohexyl]ethanamide'>H9J</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dte OCA], [https://pdbe.org/6dte PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dte RCSB], [https://www.ebi.ac.uk/pdbsum/6dte PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dte ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A125HFC0_9BURK A0A125HFC0_9BURK] Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.[HAMAP-Rule:MF_00364][SAAS:SAAS00634279] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC beta-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important beta-lactams against a clinically relevant strain of Pseudomonas aeruginosa. | ||
| - | + | A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to beta-lactams in Pseudomonas aeruginosa.,Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA Chem Commun (Camb). 2018 Sep 25;54(75):10630-10633. doi: 10.1039/c8cc05281f. Epub, 2018 Sep 4. PMID:30178799<ref>PMID:30178799</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6dte" style="background-color:#fffaf0;"></div> |
| - | [[Category: Mark | + | |
| + | ==See Also== | ||
| + | *[[Beta-Hexosaminidase|Beta-Hexosaminidase]] | ||
| + | *[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]] | ||
| + | *[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Burkholderia cenocepacia]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mark BL]] | ||
| + | [[Category: Winogrodzki JL]] | ||
Current revision
GlcNAc-inspired cyclophellitol bound to NagZ
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