Sulfatase

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<StructureSection load='1vz4' size='340' side='right' caption='Alkylsulfatase complex with succinate and Fe+2 ion (PDB code [[1vz4]])' scene=''>
<StructureSection load='1vz4' size='340' side='right' caption='Alkylsulfatase complex with succinate and Fe+2 ion (PDB code [[1vz4]])' scene=''>
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__TOC__
== Function ==
== Function ==
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* '''Estrone sulfatase''' hydrolyzes sulfated steroids.<br />
* '''Estrone sulfatase''' hydrolyzes sulfated steroids.<br />
* '''N-acetylgalactosamine-6-sulfatase''' hydrolyzes chondroitin sulfate and keratin sulfate. For details see [[Molecular Playground/Human Galactosamine-6-sulfatase]].<br />
* '''N-acetylgalactosamine-6-sulfatase''' hydrolyzes chondroitin sulfate and keratin sulfate. For details see [[Molecular Playground/Human Galactosamine-6-sulfatase]].<br />
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* '''Choline sulfatase''' hydrolyzes alkyl sulfate choline-O-sulfate<ref>PMID:29458126</ref>.<br />
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* '''Iota-carrageenan sulfatase''' hydrolyzes sulfated polysaccharides<ref>PMID:25207269</ref>.<br />
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* '''Steryl sulfatase''' converts estrone sulfate into estrogen<ref>PMID:12466383</ref>.<br />
== Disease ==
== Disease ==
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Mutations in arylsulfatase result in lysosomal storage disorders. Sulfatases are implicated in pathophysiological conditions in hormone-dependent cancer, developmental abnormalities and bacterial pathogenesis<ref>PMID:12757705</ref>.
Mutations in arylsulfatase result in lysosomal storage disorders. Sulfatases are implicated in pathophysiological conditions in hormone-dependent cancer, developmental abnormalities and bacterial pathogenesis<ref>PMID:12757705</ref>.
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*<scene name='72/725358/Cv/2'>Succinate/Fe+2 ion binding site</scene>.
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*<scene name='72/725358/Cv/3'>Succinate/Fe+2 ion binding site</scene>.
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</StructureSection>
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== 3D Structures of sulfatase ==
== 3D Structures of sulfatase ==
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[[Sulfatase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Arylsulfatase
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**[[1fsu]] – hAS B – human<br />
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**[[1auk]], [[1n2k]], [[1n2l]] – hAS A<br />
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**[[1e2s]], [[1e3c]], [[1e1z]], [[1e33]] – hAS A (mutant)<br />
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**[[1p49]] – hAS C<br />
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**[[4upi]], [[4upl]] – AS – ''Ruegeria pomeroyi''<br />
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**[[1hdh]] – PaAS – ''Pseudomonas aeruginosa''<br />
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**[[4cxk]], [[4cyr]], [[5aj9]] – PaAS (mutant)<br />
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**[[4cxs]], [[4cys]], [[4cxu]] – PaAS (mutant) + phenylphosphonate<br />
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*Alkylsulfatase
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**[[1oih]] – PpATSK – ''Pseudomonas putida''<br />
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**[[1oii]] – PpATSK + oxoglutarate + Fe<br />
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**[[1vz4]] – PpATSK + succinate + Fe<br />
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**[[1vz5]] – PpATSK + succinate <br />
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**[[1oij]] – PpATSK + oxoglutarate <br />
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**[[1oik]] – PpATSK + oxoglutarate + Fe + hexanesulfonic acid<br />
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**[[2yhe]] – sec-ATSK – ''Pseudomonas''<br />
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**[[4ffa]] – ATSK – ''Mycobacterium tuberculosis''<br />
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**[[5aij]], [[5ajl]] – PaATSK <br />
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**[[5aj9]] – PaATSK (mutant)<br />
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*Estrone sulfatase
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**[[1p49]] – hES <br />
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*N-acetylgalactosamine-6-sulfatase
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**[[4fdi]] – hGalNS <br />
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**[[4fdj]] – hGalNS + GalNac<br />
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*2-O-glycosaminoglycan sulfatase
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**[[5g2u]] – BtOGS - ''Bacterioides thetaiotaomicron''<br />
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**[[5g2t]] – BtOGS + disulfo-glucosamine + sulfo-threo-enopyranuronic acid<br />
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*Iduronate-2-sulfatase
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**[[5fql]] – hIS <br />
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**[[5g2t]] – hIS + uronic acid derivative<br />
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**[[5g2v]] – hIS + substrate<br />
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*Choline sulfatase
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**[[4ug4]], [[6fny]] – ChoS - ''Sinrhizobium melioti''<br />
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*Iota-carrageenan sulfatase
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**[[6bia]] – PtICS - ''Pseudal teromonas''<br />
 
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**[[6boj]], [[6b0k]], [[6b1v]] – PtICS + polysaccharide <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Alkylsulfatase complex with succinate and Fe+2 ion (PDB code 1vz4)

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References

  1. ↑ Hanson SR, Best MD, Wong CH. Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility. Angew Chem Int Ed Engl. 2004 Nov 5;43(43):5736-63. PMID:15493058 doi:http://dx.doi.org/10.1002/anie.200300632
  2. ↑ van Loo B, Schober M, Valkov E, Heberlein M, Bornberg-Bauer E, Faber K, Hyvonen M, Hollfelder F. Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester. J Mol Biol. 2018 Feb 16. pii: S0022-2836(18)30081-0. doi:, 10.1016/j.jmb.2018.02.010. PMID:29458126 doi:http://dx.doi.org/10.1016/j.jmb.2018.02.010
  3. ↑ Genicot SM, Groisillier A, Rogniaux H, Meslet-Cladiere L, Barbeyron T, Helbert W. Discovery of a novel iota carrageenan sulfatase isolated from the marine bacterium Pseudoalteromonas carrageenovora. Front Chem. 2014 Aug 26;2:67. doi: 10.3389/fchem.2014.00067. eCollection 2014. PMID:25207269 doi:http://dx.doi.org/10.3389/fchem.2014.00067
  4. ↑ Miki Y, Nakata T, Suzuki T, Darnel AD, Moriya T, Kaneko C, Hidaka K, Shiotsu Y, Kusaka H, Sasano H. Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues. J Clin Endocrinol Metab. 2002 Dec;87(12):5760-8. PMID:12466383 doi:10.1210/jc.2002-020670
  5. ↑ Dierks T, Schmidt B, Borissenko LV, Peng J, Preusser A, Mariappan M, von Figura K. Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme. Cell. 2003 May 16;113(4):435-44. PMID:12757705

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Michal Harel, Alexander Berchansky

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