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2vn8

From Proteopedia

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[[Image:2vn8.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of human Reticulon 4 interacting protein 1 in complex with NADPH==
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|PDB= 2vn8 |SIZE=350|CAPTION= <scene name='initialview01'>2vn8</scene>, resolution 2.10&Aring;
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<StructureSection load='2vn8' size='340' side='right'caption='[[2vn8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Binding+Site+For+Residue+Ndp+A+600'>AC1</scene>, <scene name='pdbsite=AC2:Binding+Site+For+Residue+Ndp+B+600'>AC2</scene>, <scene name='pdbsite=AC3:Binding+Site+For+Residue+Na+A+1397'>AC3</scene>, <scene name='pdbsite=AC4:Binding+Site+For+Residue+Gol+B+1397'>AC4</scene> and <scene name='pdbsite=AC5:Binding+Site+For+Residue+Cit+A+1398'>AC5</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>
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<table><tr><td colspan='2'>[[2vn8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VN8 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vn8 OCA], [https://pdbe.org/2vn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vn8 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vn8 OCA], [http://www.ebi.ac.uk/pdbsum/2vn8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vn8 RCSB]</span>
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== Disease ==
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}}
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[https://www.uniprot.org/uniprot/RT4I1_HUMAN RT4I1_HUMAN] Autosomal recessive isolated optic atrophy. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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'''CRYSTAL STRUCTURE OF HUMAN RETICULON 4 INTERACTING PROTEIN 1 IN COMPLEX WITH NADPH'''
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[https://www.uniprot.org/uniprot/RT4I1_HUMAN RT4I1_HUMAN] Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.[UniProtKB:Q924D0]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2VN8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VN8 OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vn8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vn8 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins J]]
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[[Category: Elkins, J.]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Guo K]]
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[[Category: Guo, K.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W.]]
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[[Category: Roos AK]]
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[[Category: Roos, A K.]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: alternative splicing]]
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[[Category: mitochondrion]]
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[[Category: receptor inhibitor]]
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[[Category: transit peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:13:41 2008''
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Current revision

Crystal structure of human Reticulon 4 interacting protein 1 in complex with NADPH

PDB ID 2vn8

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