Aspartate carbamoyltransferase

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ATC is composed of <scene name='59/592660/Cv/10'>2 trimers of catalytic subunits (C) and 3 dimers of regulatory subunits (R)</scene>. Click to see <scene name='59/592660/Cv/11'>two catalytic trimers</scene> and <scene name='59/592660/Cv/12'>three regulatory dimers</scene>. The <scene name='59/592660/Cv/13'>catalytic subunit</scene> contains an <scene name='59/592660/Cv/14'>aspartate-binding domain</scene> and a carbamoyl-phosphate-binding domain. The regulatory subunit contains a nucleotide effectors-binding domain and a zinc domain. <ref>PMID:10651286</ref>
ATC is composed of <scene name='59/592660/Cv/10'>2 trimers of catalytic subunits (C) and 3 dimers of regulatory subunits (R)</scene>. Click to see <scene name='59/592660/Cv/11'>two catalytic trimers</scene> and <scene name='59/592660/Cv/12'>three regulatory dimers</scene>. The <scene name='59/592660/Cv/13'>catalytic subunit</scene> contains an <scene name='59/592660/Cv/14'>aspartate-binding domain</scene> and a carbamoyl-phosphate-binding domain. The regulatory subunit contains a nucleotide effectors-binding domain and a zinc domain. <ref>PMID:10651286</ref>
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</StructureSection>
 
==3D structures of aspartate carbamoyltransferase==
==3D structures of aspartate carbamoyltransferase==
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[[Aspartate carbamoyltransferase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*ATC
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**[[2atc]], [[3at1]], [[6at1]], [[1pg5]], [[3d7s]], [[4wto]] – EcATC C+R subunits – ''Escherichia coli''<br />
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**[[9atc]] – EcATC C (mutant) + R (mutant) subunits <br />
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**[[1ezz]], [[4e2f]] – EcATC C (mutant) + R subunits <br />
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**[[2qg9]], [[2qgf]] – EcATC C + R (mutant) subunits <br />
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**[[3csu]] – EcATC C <br />
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**[[5vmq]], [[3npm]] – EcATC C (mutant) <br />
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**[[2be7]] – ATC C (mutant) + R subunits – ''Moritella profunda'' <br />
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**[[2at2]], [[3r7d]], [[3r7f]] – BsATC – ''Bacillus subtilis''<br />
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**[[2rgw]], [[3e2p]], [[4ekn]] – MjATC C subunit – ''Methanocaldococcus jannaschii''<br />
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**[[3lxm]] – ATC C subunit – ''Yersinia pestis''<br />
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**[[5ilq]], [[5iln]] – ATC – ''Plasmodium falciparum''<br />
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*ATC binary complex
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**[[1at1]] – EcATC C+R subunits + malonate<br />
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**[[1sku]] – EcATC C (mutant) +R subunits + malonate<br />
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**[[1r0b]] – EcATC C+R subunits + citrate<br />
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**[[1r0c]] – EcATC C+R subunits + N-carbamoyl-L-aspartate + phosphate<br />
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**[[1xjw]] – EcATC C (mutant) +R subunits + PALA <br />
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**[[1sku]] – EcATC C (mutant) +R subunits + phosphonoacetamide<br />
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**[[1tu0]] – EcATC C+R subunits + maltose<br />
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**[[4at1]] – EcATC C+R subunits + ATP<br />
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**[[5at1]], [[1raa]], [[1rab]], [[1rac]], [[1rad]], [[1rae]], [[1raf]], [[1rag]], [[1rah]], [[1rai]], [[1za1]], [[4fyw]] – EcATC C+R subunits + CTP<br />
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**[[8atc]], [[1acm]], [[1d09]], [[1q95]] – EcATC C+R subunits + PALA<br />
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**[[1f1b]], [[1i5o]], [[1tth]] – EcATC C (mutant) +R subunits + PALA<br />
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**[[2h3e]], [[2ipo]] – EcATC C+R subunits + phosphonacetyl asparagine<br />
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**[[1nbe]] – EcATC C (mutant) + R (mutant) subunits + malate<br />
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**[[2a0f]] – EcATC C (mutant) +R subunits + phosphonoacetamide<br />
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**[[3mpu]] – EcATC C (mutant) +R subunits + phosphate<br />
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**[[1ekx]] – EcATC C + bisubstrate analog<br />
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**[[1ml4]] – ATC C + bisubstrate analog – ''Pyrococcus abyssi''<br />
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**[[2be9]] – ATC C+R subunits + CTP – ''Sulfolobus acidocaldarius''<br />
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**[[2yww]] – MjATC R subunit + ATP <br />
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**[[3d6n]] – AaATC + dihydroorotase – ''Aqiufex aeolicus''<br />
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**[[3r7l]] – BsATC + PALA<br />
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*ATC ternary complex
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**[[7at1]] – EcATC C+R subunits + ATP + maltose<br />
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**[[8at1]] – EcATC C+R subunits + CTP + maltose<br />
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**[[4fyv]] – EcATC C+R subunits + dCTP + phosphate<br />
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**[[4fyx]] – EcATC C+R subunits + dCTP + UTP<br />
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**[[4fyy]] – EcATC C+R subunits + CTP + UTP<br />
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**[[1za2]] – EcATC C+R subunits + CTP + phosphoric monoformamide ester<br />
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**[[2air]] – EcATC C+R subunits + L-alanosine + phosphoric monoformamide ester<br />
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**[[2fzc]], [[2fzg]] – EcATC C+R subunits + CTP + phosphonic acid derivative<br />
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**[[2fzk]] – EcATC C+R subunits + CTP + phosphonacetyl benzoate<br />
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**[[4f04]], [[4kgv]], [[4kgx]], [[4kgz]], [[4kh0]] – EcATC C+R subunits + nucleotide + PALA<br />
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**[[2h3e]] – EcATC C+R subunits + phosphonacetyl asparagine + malate<br />
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**[[2at1]] – EcATC C+R subunits + phosphonacetamide + malate<br />
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**[[2hse]] – EcATC C+R subunits + phosphonacetamide + aspartate<br />
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**[[3d6n]], [[4bjh]] – AaATC + dihydroorotase + PALA <br />
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*ATC quaternary complex
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**[[1tug]] – EcATC C (mutant) +R subunits + phosphate + aspartate + phosphonoacetamide<br />
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**[[1tug]] – EcATC C (mutant) +R subunits + CTP + malonate + phosphonoacetamide<br />
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**[[4kh1]] – EcATC C+R subunits + UTP + CTP + phosphate + phosphonacetyl aspartate<br />
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}}
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== References ==
== References ==

Current revision

Structure of E. coli aspartate carbamoyltransferase catalytic (cyan and pink) and regulatory (green and yellow) subunits complex with inhibitor PALA and Zn+2 ions (grey) (PDB code 1d09).

Drag the structure with the mouse to rotate

References

  1. ↑ Jin L, Stec B, Lipscomb WN, Kantrowitz ER. Insights into the mechanisms of catalysis and heterotropic regulation of Escherichia coli aspartate transcarbamoylase based upon a structure of the enzyme complexed with the bisubstrate analogue N-phosphonacetyl-L-aspartate at 2.1 A. Proteins. 1999 Dec 1;37(4):729-42. PMID:10651286

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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