User:Charlotte Dietschy/Sandbox 1486
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| - | == | + | ==6 FIN(DDR1)== |
<StructureSection load='6fin' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='6fin' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | This is a default text for your page '''Charlotte Dietschy/Sandbox 1486'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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6FIN, also called DDR1 (Discodein Domain Receptor 1), is a receptor of the collagen. | 6FIN, also called DDR1 (Discodein Domain Receptor 1), is a receptor of the collagen. | ||
== Function == | == Function == | ||
6 FIN is part of the RTKs family (Receptor Tyrosyne Kinases) which play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. | 6 FIN is part of the RTKs family (Receptor Tyrosyne Kinases) which play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. | ||
| - | 6FIN is a transferase, so it is an Enzym which catalyses the transfer reaction of a functional group from a donor molecule to an acceptor one. | + | |
| - | + | 6FIN is a transferase, so it is an Enzym which catalyses the transfer reaction of a functional group from a donor molecule to an acceptor one. The DDR1 attaches to the collagen and binds to the cellular tissues, so the collagen can bind to the cell. | |
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== Disease == | == Disease == | ||
| + | The binding of the collagen thanks to DDR1 (fibrosis) impacts several organs: it disrupts normal organs architectur and leads to organ function loss. | ||
== Relevance == | == Relevance == | ||
| + | DDR1 is the subject for the development of novel antifibrotic medications. The inhibition of this protein prevents the diseases progression because it prohibits the link between the collagen and the cell. The inhibition of the DDR1 can stop or reduces the uncontrolled process characterised by the progressive accumulation of extra cellular matrix(ECM), mainly collagen. | ||
== Structural highlights == | == Structural highlights == | ||
| - | The DDR1 is a protein of 78.1kDa | + | The DDR1 is a protein of 78.1kDa. |
| - | + | ===Primary Structure=== | |
| + | The DDR1 contains 321 amino-acids. | ||
| + | ===Secundary Structure=== | ||
| + | 6 FIN is formed of 6 principle α-helix. | ||
| + | ===TertiaryStructure=== | ||
| + | This protein can bind to 7 ions iodure and a molecule 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one. | ||
| + | <table><tr><td colspan='2'>Multicopper Oxidase CueO [[4e9s]] is a protein containing one chain with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E9S FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT: 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one.'>3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one</scene>[[Image:imgsrv.png|thumb|middle|'''Figure 1:''' 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one.<ref>PDB image</ref>]], <scene name='pdbligand=CU:COPPER+(II)+ION'>Copper</scene></td></tr> | ||
| + | <tr id='ligands'><td class="sblockLbl"><b>[[ligands|ligands:]]</b></td><td class="sblockDat">I iodure</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e9s OCA], [http://pdbe.org/4e9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e9s RCSB], [http://www.ebi.ac.uk/pdbsum/4e9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e9s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
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</StructureSection> | </StructureSection> | ||
| - | + | [[Image:interaction.jpg]] | |
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Current revision
6 FIN(DDR1)
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![Figure 1: 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one.](/wiki/index.php/Image:Imgsrv.png)
