User:Charlotte Dietschy/Sandbox 1486
From Proteopedia
< User:Charlotte Dietschy(Difference between revisions)
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==6 FIN(DDR1)== | ==6 FIN(DDR1)== | ||
<StructureSection load='6fin' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='6fin' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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6FIN, also called DDR1 (Discodein Domain Receptor 1), is a receptor of the collagen. | 6FIN, also called DDR1 (Discodein Domain Receptor 1), is a receptor of the collagen. | ||
== Function == | == Function == | ||
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== Disease == | == Disease == | ||
| - | The binding of the collagen thanks to DDR1 (fibrosis) impacts several organs: it disrupts normal organs architectur and leads to organ function loss. | + | The binding of the collagen thanks to DDR1 (fibrosis) impacts several organs: it disrupts normal organs architectur and leads to organ function loss. |
== Relevance == | == Relevance == | ||
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===TertiaryStructure=== | ===TertiaryStructure=== | ||
This protein can bind to 7 ions iodure and a molecule 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one. | This protein can bind to 7 ions iodure and a molecule 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one. | ||
| + | <table><tr><td colspan='2'>Multicopper Oxidase CueO [[4e9s]] is a protein containing one chain with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E9S FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT: 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one.'>3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one</scene>[[Image:imgsrv.png|thumb|middle|'''Figure 1:''' 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one.<ref>PDB image</ref>]], <scene name='pdbligand=CU:COPPER+(II)+ION'>Copper</scene></td></tr> | ||
| + | <tr id='ligands'><td class="sblockLbl"><b>[[ligands|ligands:]]</b></td><td class="sblockDat">I iodure</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e9s OCA], [http://pdbe.org/4e9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e9s RCSB], [http://www.ebi.ac.uk/pdbsum/4e9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e9s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
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| + | |||
| + | </StructureSection> | ||
[[Image:interaction.jpg]] | [[Image:interaction.jpg]] | ||
Current revision
6 FIN(DDR1)
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![Figure 1: 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one.](/wiki/index.php/Image:Imgsrv.png)
