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Neprilysin

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Current revision (09:51, 21 January 2024) (edit) (undo)
 
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== Relevance ==
== Relevance ==
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NEP signaling has also been implicated in cardiovascular disease.<ref>PMID: 21046489</ref> NEP level increases in Alzheimer's disease patients<ref>PMID: 19606063</ref>. NEP inhibitors are tested as analgesics and anti-hypertensive agents.
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NEP signaling has also been implicated in cardiovascular disease.<ref>PMID: 21046489</ref> NEP level increases in Alzheimer's disease patients<ref>PMID: 19606063</ref>. NEP inhibitors like [[Sacubitril]] and [[Sacubitril/valsartan]] are tested as analgesics and anti-hypertensive agents.
== Structural highlights ==
== Structural highlights ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[6gid]] - hNEP extracellular domain - human<br />
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[[6gid]] - hNEP extracellular domain 52-750 - human<br />
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[[6sh1]] - hNEP extracellular domain (mutant)<br />
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[[6sh2]] - hNEP extracellular domain (mutant) + natriuretic peptide<br />
[[1dmt]] – hNEP extracellular domain + Zn + phosphoramidon <br />
[[1dmt]] – hNEP extracellular domain + Zn + phosphoramidon <br />
[[4cth]] - hNEP extracellular domain (mutant) + Zn + phosphoramidon<br />
[[4cth]] - hNEP extracellular domain (mutant) + Zn + phosphoramidon<br />
[[5jmy]] - hNEP extracellular domain + subitril<br />
[[5jmy]] - hNEP extracellular domain + subitril<br />
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[[1r1h]], [[1r1i]], [[1r1j]], [[1y8j]], [[2qpj]], [[2yb9]] - hNEP extracellular domain + Zn + inhibitor<br />
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[[1r1h]], [[1r1i]], [[1r1j]], [[1y8j]], [[2qpj]], [[2yb9]], [[6suk]], [[6svy]], [[6thp]], [[6xvp]] - hNEP extracellular domain + Zn + inhibitor<br />
[[2yvc]] – NEP cytoplasmic tail + radixin - mouse<br />
[[2yvc]] – NEP cytoplasmic tail + radixin - mouse<br />
[[4xbh]] - rNEP - rabbit<br />
[[4xbh]] - rNEP - rabbit<br />

Current revision

Structure of glycosylated human neprilysin extracellular domain complex with phosphoramidon and Zn+2 ion (grey) (PDB entry 1dmt)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Brenton Horne

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