Neprilysin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:51, 21 January 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 4: Line 4:
== Relevance ==
== Relevance ==
-
NEP signaling has also been implicated in cardiovascular disease.<ref>PMID: 21046489</ref> NEP level increases in Alzheimer's disease patients<ref>PMID: 19606063</ref>. NEP inhibitors are tested as analgesics and anti-hypertensive agents.
+
NEP signaling has also been implicated in cardiovascular disease.<ref>PMID: 21046489</ref> NEP level increases in Alzheimer's disease patients<ref>PMID: 19606063</ref>. NEP inhibitors like [[Sacubitril]] and [[Sacubitril/valsartan]] are tested as analgesics and anti-hypertensive agents.
== Structural highlights ==
== Structural highlights ==
Line 12: Line 12:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-
[[6gid]] - hNEP extracellular domain - human<br />
+
[[6gid]] - hNEP extracellular domain 52-750 - human<br />
 +
[[6sh1]] - hNEP extracellular domain (mutant)<br />
 +
[[6sh2]] - hNEP extracellular domain (mutant) + natriuretic peptide<br />
[[1dmt]] – hNEP extracellular domain + Zn + phosphoramidon <br />
[[1dmt]] – hNEP extracellular domain + Zn + phosphoramidon <br />
[[4cth]] - hNEP extracellular domain (mutant) + Zn + phosphoramidon<br />
[[4cth]] - hNEP extracellular domain (mutant) + Zn + phosphoramidon<br />
[[5jmy]] - hNEP extracellular domain + subitril<br />
[[5jmy]] - hNEP extracellular domain + subitril<br />
-
[[1r1h]], [[1r1i]], [[1r1j]], [[1y8j]], [[2qpj]], [[2yb9]] - hNEP extracellular domain + Zn + inhibitor<br />
+
[[1r1h]], [[1r1i]], [[1r1j]], [[1y8j]], [[2qpj]], [[2yb9]], [[6suk]], [[6svy]], [[6thp]], [[6xvp]] - hNEP extracellular domain + Zn + inhibitor<br />
[[2yvc]] – NEP cytoplasmic tail + radixin - mouse<br />
[[2yvc]] – NEP cytoplasmic tail + radixin - mouse<br />
[[4xbh]] - rNEP - rabbit<br />
[[4xbh]] - rNEP - rabbit<br />

Current revision

Structure of glycosylated human neprilysin extracellular domain complex with phosphoramidon and Zn+2 ion (grey) (PDB entry 1dmt)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Brenton Horne

Retrieved from "http://52.214.119.220/wiki/index.php/Neprilysin"
Personal tools