|
|
| (4 intermediate revisions not shown.) |
| Line 1: |
Line 1: |
| | | | |
| | ==The structure of the Plasmodium falciparum 20S proteasome.== | | ==The structure of the Plasmodium falciparum 20S proteasome.== |
| - | <StructureSection load='6muw' size='340' side='right'caption='[[6muw]], [[Resolution|resolution]] 3.80Å' scene=''> | + | <SX load='6muw' size='340' side='right' viewer='molstar' caption='[[6muw]], [[Resolution|resolution]] 3.60Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6muw]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_(isolate_3d7) Plasmodium falciparum (isolate 3d7)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MUW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6muw]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MUW FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6mux|6mux]], [[6muv|6muv]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6muw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6muw OCA], [https://pdbe.org/6muw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6muw RCSB], [https://www.ebi.ac.uk/pdbsum/6muw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6muw ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6muw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6muw OCA], [http://pdbe.org/6muw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6muw RCSB], [http://www.ebi.ac.uk/pdbsum/6muw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6muw ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/Q8IKC9_PLAF7 Q8IKC9_PLAF7]] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.[RuleBase:RU004203] [[http://www.uniprot.org/uniprot/Q8IDG3_PLAF7 Q8IDG3_PLAF7]] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.[RuleBase:RU000551] [[http://www.uniprot.org/uniprot/Q8I6T3_PLAF7 Q8I6T3_PLAF7]] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.[RuleBase:RU004203] [[http://www.uniprot.org/uniprot/Q8IJT1_PLAF7 Q8IJT1_PLAF7]] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.[RuleBase:RU004203] [[http://www.uniprot.org/uniprot/Q7K6A9_PLAF7 Q7K6A9_PLAF7]] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.[RuleBase:RU004203] [[http://www.uniprot.org/uniprot/Q8IDG2_PLAF7 Q8IDG2_PLAF7]] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.[RuleBase:RU000551] [[http://www.uniprot.org/uniprot/C0H4E8_PLAF7 C0H4E8_PLAF7]] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.[RuleBase:RU004203] [[http://www.uniprot.org/uniprot/Q8IBI3_PLAF7 Q8IBI3_PLAF7]] The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.[RuleBase:RU000551] | + | [https://www.uniprot.org/uniprot/Q8IAR3_PLAF7 Q8IAR3_PLAF7] |
| | + | |
| | + | ==See Also== |
| | + | *[[Proteasome 3D structures|Proteasome 3D structures]] |
| | __TOC__ | | __TOC__ |
| - | </StructureSection> | + | </SX> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Proteasome endopeptidase complex]] | + | [[Category: Plasmodium falciparum 3D7]] |
| - | [[Category: Gillett, D L]] | + | [[Category: Gillett DL]] |
| - | [[Category: Griffin, M D.W]] | + | [[Category: Griffin MDW]] |
| - | [[Category: Hanssen, E]] | + | [[Category: Hanssen E]] |
| - | [[Category: Leis, A P]] | + | [[Category: Leis AP]] |
| - | [[Category: Metcalfe, R D]] | + | [[Category: Metcalfe RD]] |
| - | [[Category: Tilley, L]] | + | [[Category: Tilley L]] |
| - | [[Category: Xie, S C]] | + | [[Category: Xie SC]] |
| - | [[Category: Hydrolase]]
| + | |
| - | [[Category: Protease]]
| + | |
| - | [[Category: Proteasome]]
| + | |
