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Sulfatase

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<StructureSection load='1vz4' size='340' side='right' caption='Alkylsulfatase complex with succinate and Fe+2 ion (PDB code [[1vz4]])' scene=''>
<StructureSection load='1vz4' size='340' side='right' caption='Alkylsulfatase complex with succinate and Fe+2 ion (PDB code [[1vz4]])' scene=''>
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__TOC__
== Function ==
== Function ==
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*<scene name='72/725358/Cv/3'>Succinate/Fe+2 ion binding site</scene>.
*<scene name='72/725358/Cv/3'>Succinate/Fe+2 ion binding site</scene>.
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</StructureSection>
 
== 3D Structures of sulfatase ==
== 3D Structures of sulfatase ==
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[[Sulfatase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Arylsulfatase
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**[[1fsu]] – hAS B – human<br />
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**[[1auk]], [[1n2k]], [[1n2l]] – hAS A<br />
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**[[1e2s]], [[1e3c]], [[1e1z]], [[1e33]] – hAS A (mutant)<br />
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**[[1p49]] – hAS C<br />
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**[[4upi]], [[4upl]] – AS – ''Ruegeria pomeroyi''<br />
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**[[1hdh]] – PaAS – ''Pseudomonas aeruginosa''<br />
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**[[4cxk]], [[4cyr]], [[5aj9]] – PaAS (mutant)<br />
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**[[4cxs]], [[4cys]], [[4cxu]] – PaAS (mutant) + phenylphosphonate<br />
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*Alkylsulfatase
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**[[1oih]] – PpATSK – ''Pseudomonas putida''<br />
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**[[1oii]] – PpATSK + oxoglutarate + Fe<br />
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**[[1vz4]] – PpATSK + succinate + Fe<br />
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**[[1vz5]] – PpATSK + succinate <br />
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**[[1oij]] – PpATSK + oxoglutarate <br />
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**[[1oik]] – PpATSK + oxoglutarate + Fe + hexanesulfonic acid<br />
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**[[2yhe]] – sec-ATSK – ''Pseudomonas''<br />
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**[[4ffa]] – ATSK – ''Mycobacterium tuberculosis''<br />
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**[[5aij]], [[5ajl]] – PaATSK <br />
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**[[5aj9]] – PaATSK (mutant)<br />
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*Estrone sulfatase
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**[[1p49]] – hES <br />
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*N-acetylgalactosamine-6-sulfatase
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**[[4fdi]] – hGalNS <br />
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**[[4fdj]] – hGalNS + GalNac<br />
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*2-O-glycosaminoglycan sulfatase
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**[[5g2u]] – BtOGS - ''Bacterioides thetaiotaomicron''<br />
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**[[5g2t]] – BtOGS + disulfo-glucosamine + sulfo-threo-enopyranuronic acid<br />
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*Iduronate-2-sulfatase
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**[[5fql]] – hIS <br />
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**[[5g2t]] – hIS + uronic acid derivative<br />
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**[[5g2v]] – hIS + substrate<br />
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*Choline sulfatase
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**[[4ug4]], [[6fny]] – ChoS - ''Sinrhizobium melioti''<br />
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*Iota-carrageenan sulfatase
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**[[6bia]] – PtICS - ''Pseudal teromonas''<br />
 
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**[[6boj]], [[6b0k]], [[6b1v]] – PtICS + polysaccharide <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Alkylsulfatase complex with succinate and Fe+2 ion (PDB code 1vz4)

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References

  1. ↑ Hanson SR, Best MD, Wong CH. Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility. Angew Chem Int Ed Engl. 2004 Nov 5;43(43):5736-63. PMID:15493058 doi:http://dx.doi.org/10.1002/anie.200300632
  2. ↑ van Loo B, Schober M, Valkov E, Heberlein M, Bornberg-Bauer E, Faber K, Hyvonen M, Hollfelder F. Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester. J Mol Biol. 2018 Feb 16. pii: S0022-2836(18)30081-0. doi:, 10.1016/j.jmb.2018.02.010. PMID:29458126 doi:http://dx.doi.org/10.1016/j.jmb.2018.02.010
  3. ↑ Genicot SM, Groisillier A, Rogniaux H, Meslet-Cladiere L, Barbeyron T, Helbert W. Discovery of a novel iota carrageenan sulfatase isolated from the marine bacterium Pseudoalteromonas carrageenovora. Front Chem. 2014 Aug 26;2:67. doi: 10.3389/fchem.2014.00067. eCollection 2014. PMID:25207269 doi:http://dx.doi.org/10.3389/fchem.2014.00067
  4. ↑ Dierks T, Schmidt B, Borissenko LV, Peng J, Preusser A, Mariappan M, von Figura K. Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme. Cell. 2003 May 16;113(4):435-44. PMID:12757705

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