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6por
From Proteopedia
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==Antimicrobial lasso peptide ubonodin== | ==Antimicrobial lasso peptide ubonodin== | ||
| - | <StructureSection load='6por' size='340' side='right'caption='[[6por | + | <StructureSection load='6por' size='340' side='right'caption='[[6por]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6por]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6POR OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6por]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_ubonensis Burkholderia ubonensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6POR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6POR FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6por FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6por OCA], [https://pdbe.org/6por PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6por RCSB], [https://www.ebi.ac.uk/pdbsum/6por PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6por ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A105L2P0_9BURK A0A105L2P0_9BURK] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis . The topology of ubonodin is unprecedented amongst lasso peptides with 18 of its 28 amino acids found in the mechanically-bonded loop segment. Ubonodin inhibits RNA polymerase in vitro and has potent antimicrobial activity against several pathogenic members of the Burkholderia genus, most notably B. cepacia and B. multivorans , causative agents of lung infections in cystic fibrosis patients. | ||
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| + | Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex.,Cheung-Lee WL, Parry M, Zong C, Jaramillo Cartagena A, Darst S, Connell N, Russo R, Link AJ Chembiochem. 2019 Nov 25. doi: 10.1002/cbic.201900707. PMID:31765515<ref>PMID:31765515</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6por" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Burkholderia ubonensis]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cheung-Lee | + | [[Category: Cheung-Lee WL]] |
| - | [[Category: Link | + | [[Category: Link AJ]] |
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Current revision
Antimicrobial lasso peptide ubonodin
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