6pir
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Legionella effector protein MavE== | |
| - | + | <StructureSection load='6pir' size='340' side='right'caption='[[6pir]], [[Resolution|resolution]] 1.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6pir]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PIR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pir OCA], [https://pdbe.org/6pir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pir RCSB], [https://www.ebi.ac.uk/pdbsum/6pir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pir ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MAVE_LEGPH MAVE_LEGPH] Virulence effector that is indispensable for endoplasmic reticulum (ER)-mediated remodeling of the Legionella pneumophila-containing vacuole (LCV) and lysosomal evasion (PubMed:33563829). Essential for intracellular replication in human monocyte-derived macrophages (hMDMs) and amoebae, as well as for intrapulmonary proliferation in mice (PubMed:33563829).<ref>PMID:33563829</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]] | ||
| + | [[Category: Cygler M]] | ||
| + | [[Category: Voth KA]] | ||
Current revision
Crystal structure of the Legionella effector protein MavE
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