6xxw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of beta-D-Glucuronidase for Dictyoglomus thermophilum.== | |
| + | <StructureSection load='6xxw' size='340' side='right'caption='[[6xxw]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6xxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyoglomus_thermophilum_H-6-12 Dictyoglomus thermophilum H-6-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XXW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.851Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xxw OCA], [https://pdbe.org/6xxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xxw RCSB], [https://www.ebi.ac.uk/pdbsum/6xxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xxw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B5YFE0_DICT6 B5YFE0_DICT6] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The beta-d-glucuronidase DtGlcA from Dictyoglomus thermophilum was engineered to generate an active thioglycoligase that is able to catalyse the formation of numerous S-glucuronides. Its X-ray structure analysis indicated the ability of the biocatalyst to bind aromatic thiol acceptors for S-glycosylation. Noteworthily, the DtGlcA mutant was found to be the first thioligase that is able to use a natural sugar donor different from the widely used synthetic para-nitrophenyl glycosides. | ||
| - | + | Thioglycoligation of aromatic thiols using a natural glucuronide donor.,Kurdziel M, Kopec M, Paris A, Lewinski K, Lafite P, Daniellou R Org Biomol Chem. 2020 Jul 16. doi: 10.1039/d0ob00226g. PMID:32671369<ref>PMID:32671369</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6xxw" style="background-color:#fffaf0;"></div> |
| - | [[Category: Daniellou | + | |
| + | ==See Also== | ||
| + | *[[Glucuronisidase 3D structures|Glucuronisidase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dictyoglomus thermophilum H-6-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Daniellou R]] | ||
| + | [[Category: Lafite P]] | ||
Current revision
Structure of beta-D-Glucuronidase for Dictyoglomus thermophilum.
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