6sh2
From Proteopedia
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<StructureSection load='6sh2' size='340' side='right'caption='[[6sh2]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='6sh2' size='340' side='right'caption='[[6sh2]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6sh2]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6sh2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SH2 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sh2 OCA], [https://pdbe.org/6sh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sh2 RCSB], [https://www.ebi.ac.uk/pdbsum/6sh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sh2 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/NEP_HUMAN NEP_HUMAN]] Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.<ref>PMID:2531377</ref> <ref>PMID:15283675</ref> <ref>PMID:20876573</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6sh2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6sh2" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Neprilysin|Neprilysin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Acharya KR]] | |
| - | [[Category: Acharya | + | [[Category: Moss S]] |
| - | [[Category: Moss | + | [[Category: Subramanian V]] |
| - | [[Category: Subramanian | + | |
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Current revision
Crystal structure of human neprilysin E584D in complex with C-type natriuretic peptide.
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