6y2s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Escherichia coli R318A RnlA endoribonuclease (single alanine mutant of RnlA)== | |
| - | + | <StructureSection load='6y2s' size='340' side='right'caption='[[6y2s]], [[Resolution|resolution]] 3.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6y2s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y2S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.79Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y2s OCA], [https://pdbe.org/6y2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y2s RCSB], [https://www.ebi.ac.uk/pdbsum/6y2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y2s ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RNLA_ECOLI RNLA_ECOLI] Toxic component of a toxin-antitoxin (TA) module. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA.<ref>PMID:17895580</ref> <ref>PMID:19019153</ref> <ref>PMID:20980243</ref> <ref>PMID:22403819</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Garcia-Rodriguez G]] | ||
| + | [[Category: Loris R]] | ||
Current revision
Escherichia coli R318A RnlA endoribonuclease (single alanine mutant of RnlA)
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