Virus protease

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== Function ==
== Function ==
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'''Virus protease''' or '''3C protease''' are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref> F
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'''Virus protease''' or '''3C protease''' or '''virus proteinase''' are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref> F
== Disease ==
== Disease ==
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*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
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*[[Molecular Playground/Dengue Virus Protease]]<br />
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*[[FMDV 3C]] for Foot-and-Mouth virus protease<br />
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*[[FMDV 3C]] for Foot-and-Mouth virus protease
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*[[SARS Coronavirus Main Proteinase]]<br />
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== 3D Structures of Virus proteases ==
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*[[SARS-CoV-2 Coronavirus Main Protease]]<br />
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[[Virus proteases 3D strutures]]
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*[[Taylor SARS-CoV2 Protease]]<br />
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== 3D Structures of Virus protease ==
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[[Virus protease 3D structures]]
</StructureSection>
</StructureSection>
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== 3D Structures of Virus proteases ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*'''HIV-1 protease''' . See [[Immunodeficiency virus protease]]
 
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*'''HIV-2 protease''' See [[Immunodeficiency virus protease]]
 
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*'''Feline Immunodeficiency virus protease''' See [[Immunodeficiency virus protease]]
 
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*'''Simian Immunodeficiency virus protease''' See [[Immunodeficiency virus protease]]
 
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*'''Xenotropic murine leukemia virus protease'''
 
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**[[3nr6]] – XMRV-PR P14<br />
 
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**[[3p1g]] – XMRV-PR RNase H domain (mutant)<br />
 
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**[[3slz]] – XMRV-PR residues 533-657 + inhibitor<br />
 
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**[[3sm1]] – XMRV-PR residues 533-657 + pepstatin<br />
 
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**[[3sm2]] – XMRV-PR residues 533-657 + amprenavir<br />
 
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*'''Human T-cell leukemia virus protease'''
 
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**[[2b7f]] – HTLV-PV + peptide<br />
 
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**[[3lin]], [[3liq]], [[3lit]], [[3liv]], [[3lix]], [[3liy]], [[4ydg]], [[4ydf]] – HTLV-PV (mutant) + inhibitor<br />
 
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*'''Rous sarcoma virus protease'''
 
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**[[2rsp]] – RSVP - Rous sarcoma virus<br/>
 
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**[[1bai]] – RSVP + polypeptide inhibitor
 
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*'''Human Cytomegalovirus protease'''
 
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**[[1wpo]] – CMVP - human herpes virus 5<br />
 
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**[[1cmv]], [[1lay]], [[1jq6]], [[1id4]], [[1iec]], [[1ied]], [[1ief]], [[1ieg]] – CMVP (mutant) <br />
 
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**[[2wpo]], [[1jq7]] - CMVP (mutant) + inhibitor<br />
 
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**[[1njt]], [[1nju]], [[1nkk]], [[1nkm]] - CMVP (mutant) + peptide inhibitor<br />
 
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*'''Varicella-Zoster virus protease'''
 
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**[[1vzv]] - VZVP (mutant) – human herpes virus
 
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*'''Equine infectious anemia virus protease'''
 
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**[[2fmb]], [[1fmb]] – EIAVP (mutant) + inhibitor
 
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*'''Hepatitis A virus protease'''
 
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**[[1hav]] – HAVP (mutant) – hepatitis A virus <br />
 
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**[[2h9h]], [[2hal]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor<br />
 
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**[[2h6m]] – HAVP + peptide inhibitor <br />
 
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**[[1qa7]], [[3r0f]] – HAVP (mutant) + inhibitor <br />
 
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*'''Hepatitis C virus protease'''
 
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**[[2o8m]] – HCVP (mutant)<br />
 
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**[[2a4g]], [[2gvf]], [[2f9u]], [[2f9v]] – HCVP + peptide inhibitor<br />
 
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**[[6nzt]], [[6nzv]], [[6piu]], [[6piv]], [[6piw]], [[6pix]], [[6piy]], [[6piz]], [[6pj0]], [[6pj1]], [[6pj2]] – HCVP (mutant) + inhibitor<br />
 
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*'''Orf 17'''
 
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**[[3njq]] – hOrf 17 - human herpes virus 8
 
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*'''Dengue virus protease'''
 
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**[[3u1i]] – DvNs2b + peptide – Dengue virus<br />
 
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**[[3u1j]] – DvNs2b + BPTI<br />
 
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**[[2fom]] - DvNs2b/DvNs3<br />
 
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**[[4m9f]], [[4m9i]], [[4m9k]], [[4m9m]], [[3lkw]] - DvNs2b/DvNs3 (mutant)<br />
 
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**[[6mo0]], [[6mo1]], [[6mo2]] - DvNs2b residues 1394-1440 + inhibitor<br />
 
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**[[4m9t]] - DvNs2b/DvNs3 (mutant) + inhibitor<br />
 
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**[[2jlq]] – DvNs3 residues 1646-2092 <br />
 
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**[[2jlv]] – DvNs3 residues 1646-2092 + AMPPNP + RNA<br />
 
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**[[2jlr]] – DvNs3 residues 1646-2092 + AMPPNP<br />
 
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**[[2jls]] – DvNs3 residues 1646-2092 + ADP<br />
 
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**[[2jlx]], [[2jly]], [[2jlz]] – DvNs3 residues 1646-2092 + ADP + RNA<br />
 
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**[[2jlu]], [[2jlw]] – DvNs3 residues 1646-2092 + RNA<br />
 
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**[[2vbc]], [[2whx]], [[2wzq]] – DvNs3 residues 1475-2092 + peptide inhibitor<br />
 
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**[[2m9p]], [[2m9q]] – DvNs3 residues 1475-1648 + peptide inhibitor - NMR<br />
 
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**[[6izy]] – DvNs5 RNA polymerase domain residues 2742-3387 <br />
 
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**[[6izx]] – DvNs5 RNA polymerase domain residues 2742-3387 + inhibitor<br />
 
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*'''Herpes simplex virus protease'''
 
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**[[1at3]] – HSV II – human herpesvirus 2
 
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*'''Foot-and-Mouth Disease virus protease'''
 
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**[[2bhg]] – FMDV residues 1650-1857 (mutant) – Foot-and-mouth disease virus <br />
 
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**[[2jqf]], [[2j92]], [[5hm2]] – FMDV (mutant) <br />
 
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**[[2wv4]], [[2wv5]] – FMDV (mutant) + peptide <br />
 
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*'''Infectious Bronchitis virus protease'''
 
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**[[2q6d]], [[4x2z]] – IBV – infectious bronchitis virus <br />
 
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**[[2q6f]] – IBV + inhibitor
 
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*'''Yellowtail ascites virus protease'''
 
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**[[4cx8]], [[4b07]], [[4b0t]] – YAV – yellowtail ascites virus<br />
 
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**[[4b08]] – YAV + inhibitor<br />
 
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**[[4izj]], [[4izk]] – YAV Vp4 (mutant)
 
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*'''Yellow fever virus protease'''
 
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**[[6urv]] – NS2B + NS3 <br />
 
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*'''Zika virus protease'''
 
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**[[6um3]], [[6jpw]] – NS2B + NS3 <br />
 
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*'''Pseudorabies virus protease'''
 
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**[[4cx8]] – YAV – pseudorabies virus<br />
 
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*'''Coxsakievirus protease'''
 
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**[[2vb0]], [[2zty]], [[2ztz]], [[3zyd]], [[3sj8]] – CSVP <br />
 
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**[[2zu1]], [[3zye]], [[3zz3]], [[3zz4]] – CSVP (mutant) <br />
 
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**[[2ztx]] – CSVP + Zn-H2S <br />
 
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**[[2zu3]], [[3zz5]], [[3zz6]], [[3zz7]], [[3zz8]], [[3zz9]], [[3zza]], [[3zzb]], [[3sji]] – CSVP + inhibitor <br />
 
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**[[3zzc]], [[3zzd]] – CSVP (mutant) + inhibitor <br />
 
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**[[3sj9]] – CSVP (mutant) + peptide inhibitor <br />
 
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*'''Human polio virus protease'''
 
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**[[1l1n]] – HPV <br />
 
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**[[2ijd]] – HPV (mutant) <br />
 
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*'''Human rhinovirus protease'''
 
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**[[2in2]] – HRVP – human rhinovirus - NMR <br />
 
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**[[1cqq]], [[2xya]], [[5fx5]], [[5fx6]], [[6ffn]], [[6ffs]] – HRVP + inhibitor <br />
 
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**[[2b0f]] – HRVP + inhibitor – NMR <br />
 
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**[[2h6m]] – HRVP + peptide inhibitor <br />
 
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*'''Human enterovirus protease'''
 
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**[[3osy]] – HEVP 71 – human enterovirus <br />
 
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**[[3zv8]] – HEVP 68 residues 1549-1731 <br />
 
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**[[3q3x]] – HEVP B (mutant) <br />
 
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**[[3q3y]] – HEVP B (mutant) + inhibitor <br />
 
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**[[3ruo]] – HEVP B + inhibitor <br />
 
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**[[3sjk]] – HEVP 71 (mutant) + peptide inhibitor <br />
 
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**[[3sjo]], [[5bpe]], [[5hxf]], [[5wq2]] – HEVP 71 + inhibitor <br />
 
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**[[3qzq]], [[3qzr]] – HEVP 71 (mutant) + inhibitor <br />
 
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**[[3zv9]], [[3zva]], [[3zvb]], [[3zvc]], [[3zvd]], [[3zve]], [[3zvf]], [[3zvg]] – HEVP 68 + inhibitor <br />
 
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*'''Porcine epidemic diarrhea virus protease'''
 
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**[[5hyo]], [[6noz]] – PEDVP – porcine epidemic diarrhea virus <br />
 
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*'''Coronavirus protease'''
 
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**[[4wme]], [[4wmf]] – CVP (mutant)- coronavirus <br />
 
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*'''SARS coronavirus protease'''
 
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**[[3e91]], [[3ea7]], [[3ea8]], [[3ea9]], [[3eaj]] – SCVP (mutant) – SARS coronavirus <br />
 
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**[[2amd]], [[2amq]], [[2gx4]], [[2z9g]], [[2z9j]], [[2z9k]], [[2z9l]], [[2zu5]], [[4mds]], [[4tww]], [[4twy]] – SCVP + inhibitor <br />
 
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*'''SARS COV-19 protease'''
 
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**[[6y84]] – COV-19 <br />
 
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**[[6lu7]] – COV-19 + inhibitor <br />
 
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*'''Murine coronavirus protease'''
 
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**[[6jij]] – MCP + peptide inhibitor <br />
 
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*'''Coronavirus HKU4 protease'''
 
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**[[2ynb]] – CVHP + inhibitor – BAT coronavirus <br />
 
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*'''Echovirus 1 protease'''
 
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**[[5iyt]] – EV1P (mutant) + inhibitor – Echovirus 1 <br />
 
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*'''Norovirus protease'''
 
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**[[5e0g]], [[5e0h]], [[5e0j]] – NVP (mutant)+ peptide inhibitor – Norovirus <br />
 
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**[[3ur9]], [[4imq]], [[4xbb]], [[4xbc]], [[4xbd]], [[5dg6]], [[5dgj]], [[5tg1]], [[5tg2]] – NVP residues 1101-1281 + inhibitor <br />
 
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*'''Norovirus 3C-like protease'''
 
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**[[1wqs]] – NVLP – chiba virus <br />
 
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*'''Gastroentritis virus protease'''
 
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**[[2amp]] – GEVP + inhibitor – gastroenteritis virus <br />
 
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*'''Southampton virus protease'''
 
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**[[2iph]] – SVP + inhibitor – Southampton virus <br />
 
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*'''West Nile virus protease'''
 
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**[[2ggv]] - WNVP (mutant) - West Nile virus<br />
 
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**[[2ijo]] - WNVP (mutant) + BPTI<br />
 
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**[[2yol]], [[5idk]], [[2fp7]] - WNVP + peptide inhibitor<br />
 
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**[[3e90]] - WNVP + inhibitor<br />
 
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*'''African swine fever virus protease'''
 
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**[[6ljb]], [[6lj9]] – ASFV – African swine fever virus<br />
 
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}}
 
==References==
==References==
<references />
<references />
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry 1cqq)

Drag the structure with the mouse to rotate

References

  1. ↑ Wanga QM, Chen SH. Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept Sci. 2007 Feb;8(1):19-27. PMID:17305557
  2. ↑ Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7. PMID:10500114

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