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| | ==Antimicrobial lasso peptide ubonodin== | | ==Antimicrobial lasso peptide ubonodin== |
| - | <StructureSection load='6por' size='340' side='right'caption='[[6por]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='6por' size='340' side='right'caption='[[6por]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6por]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_sp._17540 Burkholderia sp. 17540]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6POR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6POR FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6por]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_ubonensis Burkholderia ubonensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6POR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6POR FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WJ58_02830 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=101571 Burkholderia sp. 17540])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6por FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6por OCA], [http://pdbe.org/6por PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6por RCSB], [http://www.ebi.ac.uk/pdbsum/6por PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6por ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6por FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6por OCA], [https://pdbe.org/6por PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6por RCSB], [https://www.ebi.ac.uk/pdbsum/6por PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6por ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Burkholderia sp. 17540]] | + | [[Category: Burkholderia ubonensis]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Cheung-Lee, W L]] | + | [[Category: Cheung-Lee WL]] |
| - | [[Category: Link, A J]] | + | [[Category: Link AJ]] |
| - | [[Category: Antibiotic]]
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| - | [[Category: Lasso peptide]]
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| - | [[Category: Ripp]]
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| Structural highlights
Publication Abstract from PubMed
We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis . The topology of ubonodin is unprecedented amongst lasso peptides with 18 of its 28 amino acids found in the mechanically-bonded loop segment. Ubonodin inhibits RNA polymerase in vitro and has potent antimicrobial activity against several pathogenic members of the Burkholderia genus, most notably B. cepacia and B. multivorans , causative agents of lung infections in cystic fibrosis patients.
Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex.,Cheung-Lee WL, Parry M, Zong C, Jaramillo Cartagena A, Darst S, Connell N, Russo R, Link AJ Chembiochem. 2019 Nov 25. doi: 10.1002/cbic.201900707. PMID:31765515[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Cheung-Lee WL, Parry M, Zong C, Jaramillo Cartagena A, Darst S, Connell N, Russo R, Link AJ. Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex. Chembiochem. 2019 Nov 25. doi: 10.1002/cbic.201900707. PMID:31765515 doi:http://dx.doi.org/10.1002/cbic.201900707
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