6x48

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'''Unreleased structure'''
 
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The entry 6x48 is ON HOLD
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==Sortilin-Progranulin Interaction With Compound 17==
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<StructureSection load='6x48' size='340' side='right'caption='[[6x48]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X48 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=UP4:N-(3,5-dichlorobenzene-1-carbonyl)-5,5-dimethyl-L-norleucine'>UP4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x48 OCA], [https://pdbe.org/6x48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x48 RCSB], [https://www.ebi.ac.uk/pdbsum/6x48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x48 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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High-throughput screening methods have been used to identify two novel series of inhibitors that disrupt progranulin binding to sortilin. Exploration of structure-activity relationships (SAR) resulted in compounds with sufficient potency and physicochemical properties to enable co-crystallization with sortilin. These co-crystal structures supported observed SAR trends and provided guidance for additional avenues for designing compounds with additional interactions within the binding site.
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Authors: Parthasarathy, G., Soisson, S.M.
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Identification of potent inhibitors of the sortilin-progranulin interaction.,Stachel SJ, Ginnetti AT, Johnson SA, Cramer P, Wang Y, Bukhtiyarova M, Krosky D, Stump C, Hurzy DM, Schlegel KA, Cooke AJ, Allen S, O'Donnell G, Ziebell M, Parthasarathy G, Getty KL, Ho T, Ou Y, Jovanovska A, Carroll SS, Pausch M, Lumb K, Mosser SD, Voleti B, Klein DJ, Soisson SM, Zerbinatti C, Coleman PJ Bioorg Med Chem Lett. 2020 Sep 1;30(17):127403. doi: 10.1016/j.bmcl.2020.127403. , Epub 2020 Jul 15. PMID:32738972<ref>PMID:32738972</ref>
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Description: Sortilin-Progranulin Interaction With Compound 17
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Soisson, S.M]]
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<div class="pdbe-citations 6x48" style="background-color:#fffaf0;"></div>
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[[Category: Parthasarathy, G]]
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==See Also==
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*[[Neurotensin receptor|Neurotensin receptor]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Parthasarathy G]]
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[[Category: Soisson SM]]

Current revision

Sortilin-Progranulin Interaction With Compound 17

PDB ID 6x48

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