6z46
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the S. acidocaldarius 20S proteasome (Saci0613/Saci0662)== | |
| + | <StructureSection load='6z46' size='340' side='right'caption='[[6z46]], [[Resolution|resolution]] 3.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6z46]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z46 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.698Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z46 OCA], [https://pdbe.org/6z46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z46 RCSB], [https://www.ebi.ac.uk/pdbsum/6z46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z46 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSA_SULAC PSA_SULAC] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Sulfolobus acidocaldarius is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III-mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control. | ||
| - | + | The proteasome controls ESCRT-III-mediated cell division in an archaeon.,Tarrason Risa G, Hurtig F, Bray S, Hafner AE, Harker-Kirschneck L, Faull P, Davis C, Papatziamou D, Mutavchiev DR, Fan C, Meneguello L, Arashiro Pulschen A, Dey G, Culley S, Kilkenny M, Souza DP, Pellegrini L, de Bruin RAM, Henriques R, Snijders AP, Saric A, Lindas AC, Robinson NP, Baum B Science. 2020 Aug 7;369(6504). pii: 369/6504/eaaz2532. doi:, 10.1126/science.aaz2532. PMID:32764038<ref>PMID:32764038</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6z46" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Proteasome 3D structures|Proteasome 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sulfolobus acidocaldarius]] | ||
| + | [[Category: Bray SM]] | ||
| + | [[Category: Robinson NP]] | ||
Current revision
Structure of the S. acidocaldarius 20S proteasome (Saci0613/Saci0662)
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