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Proteasome 3D structures

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Current revision (09:28, 14 September 2023) (edit) (undo)
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
 +
 +
*Proteasome 13S core
 +
 +
**[[7lsx]] – y13S core – yeast - Cryo EM<br />
 +
 +
*Proteasome Pre-15S core
 +
 +
**[[7ls6]] – yP15S core - Cryo EM<br />
* Proteasome 20S core
* Proteasome 20S core
**[[4r3o]], [[5le5]], [[5lex]] – h20S core – human<br />
**[[4r3o]], [[5le5]], [[5lex]] – h20S core – human<br />
-
**[[6rgq]], [[6r70]] – h20S core – Cryo EM<br />
+
**[[6rgq]], [[6r70]], [[7pg9]], [[7v5g]], [[7v5m]] – h20S core – Cryo EM<br />
-
**[[1iru]] – 20S core - bovine<br />
+
**[[1iru]] – b20S core - bovine<br />
 +
**[[7dr7]], [[8zf5]] – b20S core – Cryo EM<br />
**[[3une]] – m20S core – mouse<br />
**[[3une]] – m20S core – mouse<br />
**[[3unh]] – m20S core (immuno)<br />
**[[3unh]] – m20S core (immuno)<br />
**[[6tu3]] – r20S core – rat - Cryo EM<br />
**[[6tu3]] – r20S core – rat - Cryo EM<br />
-
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br />
+
**[[7qve]], [[8amz]] – 20S – spinach - Cryo EM<br />
-
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[6hwc]] - y20S core (mutant)<br />
+
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core<br />
-
**[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]], [[6bdf]], [[5vy4]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br />
+
**[[7ls5]], [[7tej]] – y20S core – Cryo EM<br />
 +
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[5fg7]], [[6hwc]] - y20S core (mutant)<br />
 +
**[[8t0m]] – y20S core (mutant) – Cryo EM<br />
 +
**[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]], [[6bdf]], [[5vy4]], [[8f6a]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br />
**[[6utf]], [[6uti]] – Ta20S core subunits α+β – Cryo EM<br />
**[[6utf]], [[6uti]] – Ta20S core subunits α+β – Cryo EM<br />
 +
**[[8f66]] – Ta20S core (mutant) – Cryo EM<br />
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />
**[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br />
**[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br />
Line 26: Line 39:
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
**[[6z46]] – 20S core subunits α+β – ''Sulfolobus acidocaldarius''<br />
**[[6z46]] – 20S core subunits α+β – ''Sulfolobus acidocaldarius''<br />
 +
**[[8adn]] – 20S – ''Vairimorpha necatrix'' - Cryo EM<br />
*Proteasome 20S+activator protein
*Proteasome 20S+activator protein
-
**[[6rey]], [[6kwy]], [[6xmj]] – h20S + activator PA200 – Cryo EM<br />
+
**[[7nan]], [[7nao]], [[7nap]], [[7yqc]], [[7yqd]], [[8cxb]] – h20S + PA28 activator – Cryo EM<br />
 +
**[[6rey]], [[6kwy]], [[6xmj]], [[7naq]], [[8cvs]] – h20S + activator PA200 – Cryo EM<br />
 +
**[[7qxn]], [[7qxp]], [[7qxu]], [[7qxw]], [[7qxx]], [[7qy7]], [[7qya]], [[7qyb]] – h20S + activator ZFAND5 – Cryo EM<br />
 +
**[[7nht]] – h20S + akirin-2 – Cryo EM<br />
 +
**[[7dr6]], [[7drw]] – b20S + activator – Cryo EM<br />
**[[4v7o]], [[5nif]] – y20S core+ Blm10 <br />
**[[4v7o]], [[5nif]] – y20S core+ Blm10 <br />
**[[1z7q]], [[1fnt]] – y20S core+PA26<br />
**[[1z7q]], [[1fnt]] – y20S core+PA26<br />
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**[[6utg]], [[6uth]], [[6utj]] – Ta20S core subunits α+β + activator PA26 – Cryo EM<br />
**[[6utg]], [[6uth]], [[6utj]] – Ta20S core subunits α+β + activator PA26 – Cryo EM<br />
-
*Proteasome 20S+inhibitor
+
*Proteasome 20S complex
**[[4r67]] – h20S + cancer drug<br />
**[[4r67]] – h20S + cancer drug<br />
-
**[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]], [[6avo]], [[6e5b]] - h20S + inhibitor<br />
+
**[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]], [[6avo]], [[6e5b]], [[7awe]], [[7b12]] - h20S + inhibitor<br />
**[[5a0q]] - h20S + substrate analog<br />
**[[5a0q]] - h20S + substrate analog<br />
 +
**[[8fz6]] – b20S core + PI31 inhibitor – Cryo EM<br />
**[[3unb]], [[3unf]] – m20S + inhibitor<br />
**[[3unb]], [[3unf]] – m20S + inhibitor<br />
-
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]], [[6gop]], [[6hwb]], [[6hwa]], [[6hw9]], [[6hw8]], [[6hw7]], [[6hw6]], [[6hw5]], [[6hw4]], [[6hw3]], [[6hw0]], [[6hvy]], [[6hvx]], [[6hvw]], [[6hvv]], [[6hvu]], [[6hvt]], [[6hvs]], [[6hvr]], [[6hva]], [[6hv7]], [[6hv5]], [[6hv4]], [[6hv3]], [[6huv]], [[6huu]], [[6huq]], [[6huc]], [[6hub]], [[6htr]], [[6htp]], [[6htd]], [[6htc]], [[6htb]], [[6h39]] – y20S core+inhibitor<br />
+
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]], [[6gop]], [[6hwb]], [[6hwa]], [[6hw9]], [[6hw8]], [[6hw7]], [[6hw6]], [[6hw5]], [[6hw4]], [[6hw3]], [[6hw0]], [[6hvy]], [[6hvx]], [[6hvw]], [[6hvv]], [[6hvu]], [[6hvt]], [[6hvs]], [[6hvr]], [[6hva]], [[6hv7]], [[6hv5]], [[6hv4]], [[6hv3]], [[6huv]], [[6huu]], [[6huq]], [[6huc]], [[6hub]], [[6htr]], [[6htp]], [[6htd]], [[6htc]], [[6htb]], [[6h39]], [[7o2l]] – y20S core+inhibitor<br />
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]], [[6hwf]], [[6g8n]], [[6g8m]], [[6g7f]] – y20S (mutant) + inhibitor<br />
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]], [[6hwf]], [[6g8n]], [[6g8m]], [[6g7f]] – y20S (mutant) + inhibitor<br />
-
**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br />
+
**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]], [[6zou]], [[6zp6]], [[6zp8]] - y20S core + antibiotics<br />
**[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]], [[4qby]], [[4qlq]], [[4qls]], [[4qlt]], [[4qlu]], [[4qlv]] - y20S core+ peptide inhibitor<br />
**[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]], [[4qby]], [[4qlq]], [[4qls]], [[4qlt]], [[4qlu]], [[4qlv]] - y20S core+ peptide inhibitor<br />
**[[5cz6]], [[5cz7]] - y20S (mutant) + peptide inhibitor<br />
**[[5cz6]], [[5cz7]] - y20S (mutant) + peptide inhibitor<br />
-
**[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]] – Mt20S core+inhibitor<br />
+
**[[7teo]] – y20S core + FUB1 – Cryo EM<br />
 +
**[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]], [[6ode]], [[6ocz]], [[6ocw]], [[6wnk]] – Mt20S core+inhibitor<br />
 +
**[[8d6v]], [[8d6w]], [[8d6x]], [[8d6y]] – Mt20S core+ ATPase + ATP – Cryo EM<br />
**[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br />
**[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br />
**[[4qvl]], [[4qw4]], [[4z1l]], [[3tdd]], [[4j70]] – y20S + cancer drug<br />
**[[4qvl]], [[4qw4]], [[4z1l]], [[3tdd]], [[4j70]] – y20S + cancer drug<br />
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**[[6qm7]] – Lt20S + leishmania drug – Cryo EM<br />
**[[6qm7]] – Lt20S + leishmania drug – Cryo EM<br />
**[[6td5]] – Lt20S + inhibitor – Cryo EM<br />
**[[6td5]] – Lt20S + inhibitor – Cryo EM<br />
-
**[[6tcz]] – 20S + inhibitor - ''Leishmania donovani'' – Cryo EM<br />
+
**[[7lxt]] – Pf20S + cancer drug – Cryo EM<br />
 +
**[[7lxu]], [[7lxv]] – Pf20S + inhibitor – Cryo EM<br />
 +
**[[6tcz]], [[7zyj]], [[8olu]] – 20S + inhibitor - ''Leishmania donovani'' – Cryo EM<br />
 +
**[[8f7k]] – Ta20S core + peptide – Cryo EM<br />
* Proteasome partial 20S particle
* Proteasome partial 20S particle
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**[[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br />
**[[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br />
**[[3fp9]] – MtATPase chains A-L<br />
**[[3fp9]] – MtATPase chains A-L<br />
-
**[[1j2p]] – AfPRTS α subunit<br />
+
**[[7pxa]] - MtPRTS α+β subunits + ATPase – Cryo EM<br />
 +
**[[7pxc]], [[7pxd]] - MtPRTS α+β subunits + ATPase + Pup – Cryo EM<br />
**[[2jay]] – MtPRTS β subunit<br />
**[[2jay]] – MtPRTS β subunit<br />
 +
**[[1j2p]] – AfPRTS α subunit<br />
**[[5nyw]] – PRTS β subunit – ''Yersinia bercovieri''<br />
**[[5nyw]] – PRTS β subunit – ''Yersinia bercovieri''<br />
*Proteasome partial 26S particle
*Proteasome partial 26S particle
 +
**[[7e55]] - hPRTS α type-3 subunit – Cryo EM<br />
**[[6uyi]], [[6uyj]] - hPRTS subunit 1 + ubiquitin + ADRM1 – NMR<br />
**[[6uyi]], [[6uyj]] - hPRTS subunit 1 + ubiquitin + ADRM1 – NMR<br />
**[[5l4k]] - hPRTS lid - Cryo EM<br />
**[[5l4k]] - hPRTS lid - Cryo EM<br />
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**[[1qym]], [[1uoh]] - hPRTS subunit 10<br />
**[[1qym]], [[1uoh]] - hPRTS subunit 10<br />
**[[1tr4]] - hPRTS subunit 10 – NMR<br />
**[[1tr4]] - hPRTS subunit 10 – NMR<br />
-
**[[4nik]] - hPRTS subunit 10 + single-chain Fv<br />
+
**[[4nik]] - hPRTS subunit 10 + scFv<br />
 +
**[[7iuh]] - hPRTS subunit RPN1 + antibody – Cryo EM<br />
 +
**[[7ujd]] - hPRTS subunit RPN1 + antibody + peptide – Cryo EM<br />
 +
**[[6oi4]] - hPRTS subunit RPN13+RPN2+ubiquitin<br />
**[[3t5x]] - hPRTS subunit Dss1 + PCI domain-containing protein 2<br />
**[[3t5x]] - hPRTS subunit Dss1 + PCI domain-containing protein 2<br />
**[[2dvw]], [[2dwz]] - mPRTS subunit 10 + hPRTS subunit 6B – mouse<br />
**[[2dvw]], [[2dwz]] - mPRTS subunit 10 + hPRTS subunit 6B – mouse<br />
**[[3aji]] - mPRTS subunit 10 + subunit 4<br />
**[[3aji]] - mPRTS subunit 10 + subunit 4<br />
**[[2z59]] - mPRTS subunit RPN13+ubiquitin<br />
**[[2z59]] - mPRTS subunit RPN13+ubiquitin<br />
 +
**[[8jtk]], [[8jtl]], [[8pfd]] - PRTS subunit RPN10 + SAP05 – ''Arabidosis thaliana''<br />
**[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br />
**[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br />
**[[4ady]] - yPRTS subunit RPN2<br />
**[[4ady]] - yPRTS subunit RPN2<br />
Line 123: Line 154:
*Proteasome 26S particle
*Proteasome 26S particle
-
**[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]], [[5vhs]], [[5vhr]], [[5vhq]], [[5vhp]], [[5vho]], [[5vhn]], [[5vhm]], [[5vhj]], [[5vhi]], [[5vhh]], [[5vhf]], [[5vgz]], [[5vft]], [[5vfr]], [[5vfo]] - hPRTS - Cryo EM<br />
+
**[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]], [[5vhs]], [[5vhr]], [[5vhq]], [[5vhp]], [[5vho]], [[5vhn]], [[5vhm]], [[5vhj]], [[5vhi]], [[5vhh]], [[5vhf]], [[5vgz]], [[5vft]], [[5vfr]], [[5vfo]] - h26S - Cryo EM<br />
-
**[[5m32]] - hPRTS + inhibitor - Cryo EM<br />
+
**[[6msb]], [[6msd]], [[6mse]], [[6msg]], [[6msh]], [[6msj]], [[6msk]] – h26S + ADP + ATP - Cryo EM<br />
-
**[[6wjn]] – hPRTS + ubiquitin + E3 ubiquitin ligase – Cryo EM<br />
+
**[[5m32]] - h26S + inhibitor - Cryo EM<br />
-
**[[6epf]], [[6epe]], [[6epd]], [[6epc]] – rPRTS - Cryo EM<br />
+
**[[6wjd]], [[6wjn]] – h26S + ubiquitin + E3 ubiquitin ligase – Cryo EM<br />
-
**[[3j47]], [[4cr2]], [[4cr3]], [[4cr4]], [[5wvi]], [[5mpc]] – yPRTS – Cryo EM<br />
+
**[[7w37]], [[7w38]], [[7w39]], [[7w3a]], [[7w3b]], [[7w3c]], [[7w3f]], [[7w3g]], [[7w3h]], [[7w3j]], [[7w3j]], [[7w3k]], [[7w3m]] – h26S + USP14 – Cryo EM<br />
-
**[[5wvk]] - yPRTS + ADP - Cryo EM<br />
+
**[[6epf]], [[6epe]], [[6epd]], [[6epc]] – r26S - Cryo EM<br />
-
**[[5mp9]], [[5mpa]], [[5mpd]], [[5mpe]] - yPRTS + ATP - Cryo EM<br />
+
**[[3j47]], [[4cr2]], [[4cr3]], [[4cr4]], [[5wvi]], [[5mpc]], [[6j2c]], [[6j2n]], [[6j2q]], [[6j2x]], [[6j30]], [[6fvt]], [[6fvu]], [[6fvv]], [[6fvw]], [[6fvx]], [[6fvy]] – y26S – Cryo EM<br />
-
**[[5mpb]] - yPRTS + AMPPNP - Cryo EM<br />
+
**[[5wvk]] - y26S + ADP - Cryo EM<br />
-
**[[4g4s]] – yPRTS + proteasome assembly chaperon 1 & 2<br />
+
**[[5mp9]], [[5mpa]], [[5mpd]], [[5mpe]] - y26S + ATP - Cryo EM<br />
-
**[[5a5b]] - yPRTS + UBP6 - Cryo EM<br />
+
**[[5mpb]] - y26S + AMPPNP - Cryo EM<br />
-
**[[6ef3]], [[6ef2]], [[6ef1]], [[6ef0]] – yPRTS + ubiquitin-L40 – Cryo EM<br />
+
**[[4g4s]] – y26S + proteasome assembly chaperon 1 & 2<br />
 +
**[[5a5b]] - y26S + UBP6 - Cryo EM<br />
 +
**[[6ef3]], [[6ef2]], [[6ef1]], [[6ef0]] – y26S + ubiquitin-L40 – Cryo EM<br />
 +
**[[7qo3]] – y26S + Ubp6 – Cryo EM<br />
 +
**[[7qo4]] – y26S + Ubp6 + UbVS – Cryo EM<br />
 +
**[[7qo5]], [[7qo6]] – y26S + Rpt1 + Rk + Ubp6 + UbVS – Cryo EM<br />
 +
**[[8t08]] – y26S + UMP1 + proteasome chaperone + proteasome assembly chaperone – Cryo EM<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Proteasome

Updated on 14-September-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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