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7br9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mus musculus IRG1== | |
| + | <StructureSection load='7br9' size='340' side='right'caption='[[7br9]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7br9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BR9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7br9 OCA], [https://pdbe.org/7br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7br9 RCSB], [https://www.ebi.ac.uk/pdbsum/7br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7br9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IRG1_MOUSE IRG1_MOUSE] Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:30635240, PubMed:31548418). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240). Plays a role in the embryo implantation (PubMed:14500577).<ref>PMID:14500577</ref> <ref>PMID:23609450</ref> <ref>PMID:23610393</ref> <ref>PMID:30635240</ref> <ref>PMID:31548418</ref> <ref>PMID:35662396</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | PROTEIN DATA BANK ACCESSION CODES: Coordinate and structural factors were deposited with the Protein Data Bank under PDB ID: 7BR9. | ||
| - | + | The crystal structure of mouse IRG1 suggests that cis-aconitate decarboxylase has an open and closed conformation.,Chun HL, Lee SY, Kim KH, Lee CS, Oh TJ, Park HH PLoS One. 2020 Dec 1;15(12):e0242383. doi: 10.1371/journal.pone.0242383., eCollection 2020. PMID:33259501<ref>PMID:33259501</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7br9" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Chun HL]] | ||
| + | [[Category: Park HH]] | ||
Current revision
Crystal structure of mus musculus IRG1
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